Human Technology Research Institute, Higashi, Tsukuba, Ibaraki, Japan.
Biofabrication. 2011 Jun;3(2):022001. doi: 10.1088/1758-5082/3/2/022001. Epub 2011 Apr 8.
In this review, the current knowledge of signal molecules-calcium phosphate coprecipitation and its biomedical application as a functional coating are described. Although signal molecules regulate a variety of cellular processes, it is difficult to sustain the regulation activity for a long term when the signal molecules are only injected in a free form. The signal molecules-calcium phosphate coprecipitation on a substrate surface is a very promising process to achieve sustained regulation activity of the signal molecules by controlled and localized delivery of the signal molecules to specific body sites (implantation sites). However, the significance of immobilizing signal molecules with calcium phosphate coatings and their biomedical application are not systematically illustrated. For this purpose, the presently existing coprecipitation methods and strategies on biomedical application are summarized and discussed.
在这篇综述中，描述了目前关于信号分子-磷酸钙共沉淀及其作为功能性涂层的生物医学应用的知识。虽然信号分子可以调节多种细胞过程，但当信号分子以游离形式注入时，很难长时间维持其调节活性。在基底表面上进行信号分子-磷酸钙共沉淀是一种非常有前途的方法，可以通过将信号分子受控和局部递送到特定的身体部位（植入部位）来实现信号分子的持续调节活性。然而，将信号分子固定在磷酸钙涂层上的意义及其生物医学应用尚未得到系统阐述。为此，总结和讨论了目前在生物医学应用中存在的共沉淀方法和策略。
