Parissis Haralabos
Cardiothoracic Dept, Royal Victoria Hospital, Grosvernor Rd, Belfast, BT12 6BA, Northern Ireland.
J Cardiothorac Surg. 2011 Apr 8;6:44. doi: 10.1186/1749-8090-6-44.
A treatment strategy of a difficult and unusual problem is presented. We are reporting a case of a patient who had a documented allergy to heparin and required Cardiac surgery for an ASD closure. The anticoagulation regime used during cardiopulmonary bypass was lepirudin based. This report indicates that r-hirudin provides effective anticoagulation, however unless ECT is monitoring, post operative hemorrhage is encountered. Therefore this case is unique not only because of its rarity but also by the fact that it presents the caveats encountered when ECT is not available.
本文提出了一种针对疑难罕见问题的治疗策略。我们报告了一例有肝素过敏记录且因房间隔缺损封堵术需要进行心脏手术的患者。体外循环期间使用的抗凝方案是以重组水蛭素为基础的。本报告表明重组水蛭素可提供有效的抗凝作用，然而，除非进行活化凝血时间（ACT）监测，否则会出现术后出血。因此，该病例不仅因其罕见性而独特，还因其呈现了在无法进行ACT监测时所遇到的注意事项。
