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Lepirudin as an alternative to "heparin allergy" during cardiopulmonary bypass.在体外循环期间，比伐芦定可作为“肝素过敏”的替代药物。
J Cardiothorac Surg. 2011 Apr 8;6:44. doi: 10.1186/1749-8090-6-44.
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Anticoagulation for patients with heparin-induced thrombocytopenia using recombinant hirudin during cardiopulmonary bypass.在体外循环期间使用重组水蛭素对肝素诱导的血小板减少症患者进行抗凝治疗。
J Clin Anesth. 2002 Sep;14(6):452-5. doi: 10.1016/s0952-8180(02)00386-0.
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Management of anticoagulation during cardiopulmonary bypass in a patient with allergy to heparin and heparin-like compounds: a case-report.对肝素和类肝素化合物过敏患者在体外循环期间的抗凝管理：一例报告
Blood Coagul Fibrinolysis. 2014 Dec;25(8):900-3. doi: 10.1097/MBC.0000000000000152.
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Recombinant hirudin anticoagulation for aortic valve replacement in heparin-induced thrombocytopenia.重组水蛭素抗凝用于肝素诱导的血小板减少症患者的主动脉瓣置换术
Can J Anaesth. 2000 Mar;47(3):255-60. doi: 10.1007/BF03018923.
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Use of ecarin clotting time (ECT) with lepirudin therapy in heparin-induced thrombocytopenia and cardiopulmonary bypass.在肝素诱导的血小板减少症及体外循环中使用依卡凝血时间（ECT）联合比伐卢定治疗。
J Extra Corpor Technol. 2001 May;33(2):117-25.
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Bidirectional glenn shunt surgery using lepirudin anticoagulation in an infant with heparin-induced thrombocytopenia with thrombosis.
Anesth Analg. 2005 Jul;101(1):74-6, table of contents. doi: 10.1213/01.ANE.0000153019.15297.0B.
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Recombinant hirudin for cardiopulmonary bypass anticoagulation: a randomized, prospective, and heparin-controlled pilot study.重组水蛭素用于体外循环抗凝：一项随机、前瞻性且以肝素为对照的初步研究。
Thorac Cardiovasc Surg. 2007 Jun;55(4):233-8. doi: 10.1055/s-2006-955956.
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Monitoring of hirudin therapy with the Thrombelastograph.使用血栓弹力图监测水蛭素治疗。
J Clin Anesth. 2002 Sep;14(6):456-8. doi: 10.1016/s0952-8180(02)00398-7.
引用本文的文献
1
Bivalirudin for cardiopulmonary bypass in a patient with heparin allergy.比伐卢定在肝素过敏患者体外循环中的应用。
J Cardiothorac Surg. 2023 Sep 11;18(1):258. doi: 10.1186/s13019-023-02359-2.
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Potential clinical applications of phytopharmaceuticals for the in-patient management of coagulopathies in COVID-19.植物药在 COVID-19 住院患者凝血功能障碍管理中的潜在临床应用。
Phytother Res. 2022 May;36(5):1884-1913. doi: 10.1002/ptr.7408. Epub 2022 Feb 11.
本文引用的文献
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Successful use of bivalirudin for cardiopulmonary bypass in a patient with heparin allergy.在一名肝素过敏患者中成功使用比伐卢定进行体外循环。
Perfusion. 2007 Jan;22(1):67-9. doi: 10.1177/0267659106076004.
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Recombinant hirudin for cardiopulmonary bypass anticoagulation: a randomized, prospective, and heparin-controlled pilot study.重组水蛭素用于体外循环抗凝：一项随机、前瞻性且以肝素为对照的初步研究。
Thorac Cardiovasc Surg. 2007 Jun;55(4):233-8. doi: 10.1055/s-2006-955956.
3
Alternative anticoagulation management strategies for the patient with heparin-induced thrombocytopenia undergoing cardiac surgery.接受心脏手术的肝素诱导的血小板减少症患者的替代抗凝管理策略。
J Cardiothorac Vasc Anesth. 2007 Feb;21(1):113-26. doi: 10.1053/j.jvca.2006.08.011. Epub 2006 Oct 24.
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A comparison of bivalirudin to heparin with protamine reversal in patients undergoing cardiac surgery with cardiopulmonary bypass: the EVOLUTION-ON study.在接受体外循环心脏手术的患者中，比伐芦定与肝素加鱼精蛋白逆转剂的比较：EVOLUTION-ON研究。
J Thorac Cardiovasc Surg. 2006 Mar;131(3):533-9. doi: 10.1016/j.jtcvs.2005.09.057.
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Anticoagulation management and cardiac surgery in patients with heparin-induced thrombocytopenia.肝素诱导的血小板减少症患者的抗凝管理与心脏手术
Semin Thorac Cardiovasc Surg. 2005 Spring;17(1):85-96. doi: 10.1053/j.semtcvs.2004.12.008.
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Lepirudin: a bivalent direct thrombin inhibitor for anticoagulation therapy.水蛭素：一种用于抗凝治疗的双价直接凝血酶抑制剂。
Expert Rev Cardiovasc Ther. 2004 May;2(3):339-57. doi: 10.1586/14779072.2.3.339.
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Anaphylactic and anaphylactoid reactions associated with lepirudin in patients with heparin-induced thrombocytopenia.肝素诱导的血小板减少症患者中与重组水蛭素相关的过敏反应和类过敏反应。
Circulation. 2003 Oct 28;108(17):2062-5. doi: 10.1161/01.CIR.0000096056.37269.14. Epub 2003 Oct 20.
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Heparin-induced thrombocytopenia: pathogenesis and management.肝素诱导的血小板减少症：发病机制与管理
Br J Haematol. 2003 May;121(4):535-55. doi: 10.1046/j.1365-2141.2003.04334.x.
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Recombinant hirudin in clinical practice: focus on lepirudin.
Circulation. 2001 Mar 13;103(10):1479-84. doi: 10.1161/01.cir.103.10.1479.
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