Department of Pathology and Laboratory Medicine, University of Alberta, Edmonton, ALBERTA T6G 2B7, CANADA.
J Cancer. 2011 Feb 22;2:107-15. doi: 10.7150/jca.2.107.
Human cancer classification is currently based on the idea of cell of origin, light and electron microscopic attributes of the cancer. What is not yet integrated into cancer classification are the functional attributes of these cancer cells. Recent innovative techniques in biology have provided a wealth of information on the genomic, transcriptomic and proteomic changes in cancer cells. The emergence of the concept of cancer stem cells needs to be included in a classification model to capture the known attributes of cancer stem cells and their potential contribution to treatment response, and metastases. The integrated model of cancer classification presented here incorporates all morphology, cancer stem cell contributions, genetic, and functional attributes of cancer. Integrated cancer classification models could eliminate the unclassifiable cancers as used in current classifications. Future cancer treatment may be advanced by using an integrated model of cancer classification.
目前，人类癌症的分类基于细胞起源、癌症的光镜和电镜特征的概念。尚未纳入癌症分类的是这些癌细胞的功能特征。生物学的最新创新技术为癌细胞的基因组、转录组和蛋白质组变化提供了丰富的信息。癌症干细胞概念的出现需要纳入分类模型，以捕获已知的癌症干细胞属性及其对治疗反应和转移的潜在贡献。这里提出的癌症综合分类模型纳入了所有形态学、癌症干细胞贡献、遗传和癌症功能属性。综合癌症分类模型可以消除当前分类中使用的不可分类癌症。使用癌症分类的综合模型可能会推进未来的癌症治疗。
