Department of Pediatrics, University of Toledo Health Sciences Center, Toledo, OH, USA.
J Pediatr. 2011 Sep;159(3):377-383.e1. doi: 10.1016/j.jpeds.2011.02.011. Epub 2011 Apr 9.
To report longitudinal home recordings of hemoglobin O(2) saturation by pulse oximetry (Spo(2)) during unperturbed sleep in preterm and term infants.
We recorded continuous pulse oximetry during the first 3 minutes of each hour of monitor use (nonevent epochs) for 103 preterm infants born at <1750 g and ≤ 34 weeks postmenstrual age (PMA), and 99 healthy term infants.
Median baseline Spo(2) was approximately 98% for both the preterm and term groups. Episodes of intermittent hypoxemia occurred in 74% of preterm and 62% of term infants. Among infants with intermittent hypoxemia, the number of seconds/hour of monitoring <90% Spo(2) was initially significantly greater in the preterm than the term group and declined with age at a similar rate in both groups. The 75(th) to 95(th) percentiles for seconds/hour of Spo(2) <90% in preterm infants were highest at 36 weeks PMA and progressively decreased until 44 weeks PMA, after which time they did not differ from term infants.
Clinically inapparent intermittent hypoxemia occurs in epochs unperturbed by and temporally unrelated to apnea or bradycardia events, especially in preterm infants at 36 to 44 weeks PMA.
报告早产儿和足月产儿在未受干扰的睡眠中通过脉搏血氧饱和度（SpO2）进行的长时间家庭记录。
我们记录了 103 名出生体重<1750 克且胎龄≤34 周的早产儿和 99 名健康足月产儿在使用监测器的每个小时的前 3 分钟内（无事件时段）的连续脉搏血氧饱和度。
早产儿和足月产儿的基线 SpO2 中位数均约为 98%。间歇性低氧血症在 74%的早产儿和 62%的足月产儿中发生。在间歇性低氧血症的婴儿中，监测<90%SpO2 的秒数/小时数在早产儿中最初明显高于足月产儿，并以相似的速度随年龄下降。早产儿 SpO2<90%的秒数/小时的 75%至 95%百分位数在胎龄 36 周时最高，随后逐渐下降，直至胎龄 44 周，此后与足月产儿无差异。
特别是在胎龄 36 至 44 周的早产儿中，与呼吸暂停或心动过缓事件无关且无干扰的无临床症状间歇性低氧血症会出现在时段中。
