Department of Psychology, New York University, New York, NY 10003, USA.
Hippocampus. 2012 Mar;22(3):389-98. doi: 10.1002/hipo.20933. Epub 2011 Apr 11.
The hippocampus is proposed to switch between memory encoding and retrieval by continually computing the overlap between what is expected and what is encountered. Central to this hypothesis is that area CA1 performs this calculation. However, empirical evidence for this is lacking. To test the theoretical role of area CA1 in match/mismatch detection, we had subjects study complex stimuli and then, during high-resolution fMRI scanning, make memory judgments about probes that either matched or mismatched expectations. More than any other hippocampal subfield, area CA1 displayed responses consistent with a match/mismatch detector. Specifically, the responses in area CA1 tracked the total number of changes present in the probe. Additionally, area CA1 was sensitive to both behaviorally relevant and irrelevant changes, a key feature of an automatic comparator. These results are consistent with, and provide the first evidence in humans for, the theoretically important role of area CA1 as a match/mismatch detector.
海马体被认为通过不断计算期望与遇到的事物之间的重叠来在记忆编码和检索之间切换。这一假说的核心是 CA1 区域执行此计算。然而，缺乏这方面的经验证据。为了检验 CA1 区域在匹配/不匹配检测中的理论作用，我们让受试者学习复杂的刺激，然后在高分辨率 fMRI 扫描期间对与预期相匹配或不匹配的探针进行记忆判断。与其他海马亚区相比，CA1 区域的反应更符合匹配/不匹配探测器。具体来说，CA1 区域的反应跟踪探针中存在的总变化数。此外，CA1 区域对行为相关和不相关的变化都很敏感，这是自动比较器的一个关键特征。这些结果与 CA1 区域作为匹配/不匹配探测器的理论重要性一致，并为人类提供了首个证据。
