Kiany Farin, Hedayati Azita
Oral and Dental Health Care Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, Iran.
Odontology. 2015 May;103(2):203-9. doi: 10.1007/s10266-014-0149-2. Epub 2014 Feb 14.
The present study investigated the effect of non-surgical periodontal therapy on serum level of anti-cardiolipin antibodies (aCLA), which are potentially involved in the pathogenesis of cardiovascular diseases in periodontal patients. Twenty volunteers (11 females and 9 males) with the mean age of 40.55 years participated in this study. Generalized chronic periodontitis was diagnosed through clinical periodontal examination at baseline visit. This examination included measuring the probing pocket depth and clinical attachment loss. Plaque index and gingival index were also recorded. After baseline examination, all the subjects received full-mouth non-surgical periodontal treatment. Subjects returned for a final visit 6 weeks after the last session of scaling for reevaluation of the periodontal parameters. At baseline and final visits 2 ml of venous blood was collected from each patient and an available commercially enzyme-linked immunosorbent assay was used for analyzing aCLA (IgM and IgG). The collected data were analyzed using the paired sample t test. Mean levels of both forms of aCLA, before and after treatment, showed statistically significant difference (P = 0.003 for IgM and P = 0.001 for IgG). In addition, study results showed significant reductions in periodontal parameters after non-surgical periodontal therapy (P < 0.001). The results of this study suggested that successful periodontal therapy can improve the serum level of one of the inflammatory biomarkers involved in the cardiovascular problems.
本研究调查了非手术牙周治疗对血清抗心磷脂抗体（aCLA）水平的影响，该抗体可能参与牙周病患者心血管疾病的发病机制。20名志愿者（11名女性和9名男性）参与了本研究，平均年龄为40.55岁。在基线访视时通过临床牙周检查诊断为广泛性慢性牙周炎。该检查包括测量探诊深度和临床附着丧失。还记录了菌斑指数和牙龈指数。基线检查后，所有受试者均接受全口非手术牙周治疗。在最后一次洁治后6周，受试者返回进行最后一次访视，以重新评估牙周参数。在基线和最后一次访视时，从每位患者采集2ml静脉血，并使用市售的酶联免疫吸附测定法分析aCLA（IgM和IgG）。使用配对样本t检验分析收集的数据。治疗前后两种形式的aCLA平均水平均显示出统计学上的显著差异（IgM为P = 0.003，IgG为P = 0.001）。此外，研究结果显示非手术牙周治疗后牙周参数显著降低（P < 0.001）。本研究结果表明，成功的牙周治疗可以改善参与心血管问题的炎症生物标志物之一的血清水平。
