University of North Carolina at Chapel Hill, Department of Sociology, USA.
Ann Epidemiol. 2011 Aug;21(8):598-607. doi: 10.1016/j.annepidem.2011.02.012. Epub 2011 Apr 16.
We evaluated the contributions of birth weight and current body mass index (BMI) to racial/ethnic disparities in systolic blood pressure (SBP) in the United States.
Participants were 10,046 young adults (ages 24-32) in the National Longitudinal Study of Adolescent Health. SBP, BMI, and other contemporaneous factors were assessed at Wave IV (2007-2008); birth weight and other early life factors were reported at Wave I (1994-1995). Data were analyzed using sex- and race-stratified multivariable regression models.
Racial/ethnic disparities in SBP were limited to black and white females. The black-white female disparity in SBP was 3.36 mmHg and was partially explained by current BMI, but not birth weight. Associations between birth weight and SBP were limited to males, in whom we found a decrease of 1.05 mmHg in SBP per 1-kg increase in birth weight (95% confidence interval, -1.90, -0.20). This inverse relationship strengthened after adjusting for BMI and other factors, and was strongest among black and white males. A significant association between BMI and SBP was found in all racial/ethnic and sex subgroups.
In this U.S. national cohort, birth weight is negatively associated with SBP among black and white young adult males.
我们评估了出生体重和当前体重指数（BMI）对美国人群收缩压（SBP）的种族/民族差异的影响。
参与者为国家青少年健康纵向研究中的 10046 名年轻成年人（年龄 24-32 岁）。在第四波（2007-2008 年）评估 SBP、BMI 和其他同期因素；在第一波（1994-1995 年）报告出生体重和其他早期生活因素。使用按性别和种族分层的多变量回归模型分析数据。
SBP 的种族/民族差异仅限于黑人和白人女性。SBP 的黑人和白人女性差异为 3.36mmHg，部分可以用当前 BMI 解释，但不能用出生体重解释。出生体重与 SBP 之间的关联仅限于男性，我们发现出生体重每增加 1 公斤，SBP 降低 1.05mmHg（95%置信区间，-1.90，-0.20）。这种负相关关系在调整 BMI 和其他因素后增强，在黑人和白人男性中最强。在所有种族/民族和性别亚组中均发现 BMI 与 SBP 之间存在显著关联。
在这项美国全国队列研究中，出生体重与黑人和白人年轻成年男性的 SBP 呈负相关。
