Rubin Joseph E, Ball Katherine R, Chirino-Trejo Manuel
Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Can Vet J. 2011 Feb;52(2):153-7.
This study characterized the antimicrobial susceptibility of 221 Staphylococcus aureus isolated from various species, and 60 canine Staphylococcus pseudintermedius isolated from 1986 through 2000 at the Western College of Veterinary Medicine (WCVM). Resistance of S. aureus was most common to penicillin (31%) and tetracycline (14%); resistance of S. pseudintermedius to penicillin was present in 8% and to tetracycline in 34% of isolates. Resistance to trimethoprim/sulfamethoxazole was only seen among S. pseudintermedius, and there was no resistance to amoxicillin/clavulanate, ampicillin/sulbactam, cephalothin, amikacin, gentamicin, enrofloxacin, chloramphenicol, or rifampin among any isolate. Inducible clindamycin resistance was found in both S. aureus and S. pseudintermedius, highlighting the need for careful interpretation of culture and susceptibility test results. There were significant differences in the minimum inhibitory concentrations of penicillin, ciprofloxacin, enrofloxacin, clindamycin, erythromycin, chloramphenicol, and tetracycline between avian, bovine, equine, and porcine isolates.
本研究对从不同物种分离出的221株金黄色葡萄球菌以及1986年至2000年期间在西部兽医学院（WCVM）从犬类分离出的60株中间型葡萄球菌的抗菌药敏性进行了表征。金黄色葡萄球菌对青霉素（31%）和四环素（14%）的耐药性最为常见；中间型葡萄球菌对青霉素的耐药率为8%，对四环素的耐药率为34%。仅在中间型葡萄球菌中发现对甲氧苄啶/磺胺甲恶唑的耐药性，且在任何分离株中均未发现对阿莫西林/克拉维酸、氨苄西林/舒巴坦、头孢噻吩、阿米卡星、庆大霉素、恩诺沙星、氯霉素或利福平的耐药性。在金黄色葡萄球菌和中间型葡萄球菌中均发现了诱导性克林霉素耐药性，这突出表明需要仔细解读培养和药敏试验结果。禽类、牛类、马类和猪类分离株在青霉素、环丙沙星、恩诺沙星、克林霉素、红霉素、氯霉素和四环素的最低抑菌浓度方面存在显著差异。
