Aminimoghadamfarouj Noushin, Nematollahi Alireza, Wiart Christophe
School of Pharmacy, Faculty of Science, University of Nottingham, Malaysia.
J Asian Nat Prod Res. 2011 May;13(5):465-76. doi: 10.1080/10286020.2011.570265.
One of the rich sources of lead compounds is the Angiosperms. Many of these lead compounds are useful medicines naturally, whereas others have been used as the basis for synthetic agents. These are potent and effective compounds, which have been obtained from plants, including anti-cancer (cytotoxic) agents, anti-malaria (anti-protozoal) agents, and anti-bacterial agents. Today, the number of plant families that have been extensively studied is relatively very few and the vast majorities have not been studied at all. The Annonaceae is the largest family in the order Magnoliales. It includes tropical trees, bushes, and climbers, which are often used as traditional remedies in Southeast Asia. Members of the Annonaceae have the particularity to elaborate a broad spectrum of natural products that have displayed anti-bacterial, anti-fungal, and anti-protozoal effects and have been used for the treatment of medical conditions, such as skin diseases, intestinal worms, inflammation of the eyes, HIV, and cancer. These special effects and the vast range of variation in potent compounds make the Annonaceae unique from other similar families in the Magnoliales and the Angiosperms in general. This paper attempts to summarize some important information and discusses a series of hypotheses about the effects of Annonaceae compounds.
被子植物是铅化合物的丰富来源之一。这些铅化合物中的许多本身就是有用的药物，而其他一些则被用作合成药物的基础。这些是从植物中获得的强效且有效的化合物，包括抗癌（细胞毒性）剂、抗疟疾（抗原虫）剂和抗菌剂。如今，已被广泛研究的植物科数量相对很少，绝大多数植物科根本未被研究过。番荔枝科是木兰目中最大的科。它包括热带树木、灌木和攀缘植物，在东南亚常被用作传统药物。番荔枝科成员的特殊性在于能制造出具有抗菌、抗真菌和抗原虫作用的多种天然产物，并已用于治疗皮肤病、肠道寄生虫、眼部炎症、艾滋病和癌症等病症。这些特殊作用以及强效化合物的广泛差异使得番荔枝科在木兰目以及一般的被子植物中与其他类似科有所不同。本文试图总结一些重要信息，并讨论一系列关于番荔枝科化合物作用的假说。
