Naydenov E, Tzekov C, Minkin K, Nachev S, Romansky K, Bussarsky V
Department of Neurosurgery, University Hospital 'St. Ivan Rilski', Sofia, Bulgaria.
Case Rep Oncol. 2011 Jan 4;4(1):1-11. doi: 10.1159/000323432.
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor with an extremely poor prognosis in spite of multimodal treatment approaches. The estimated median survival in cases with GBM is about 12-16 months. Those patients who survive =3 years after the initial diagnosis are defined as long-term survivors. In this study, we retrospectively analyze 50 consecutive cases of Bulgarian patients with newly diagnosed GBM surgically treated at our institution for a period of 1 year. Four of them survived for more than 36 months after the initial intervention. The histological re-examination revealed features typical of primary GBM in 3 of these cases, which are described in detail in the present paper. A brief review of the relevant literature is also given.
多形性胶质母细胞瘤（GBM）是最常见且侵袭性最强的原发性脑肿瘤，尽管采用了多模式治疗方法，其预后仍极差。GBM患者的估计中位生存期约为12 - 16个月。那些在初次诊断后存活≥3年的患者被定义为长期幸存者。在本研究中，我们回顾性分析了我院1年内手术治疗的50例新诊断为GBM的保加利亚连续病例。其中4例在初次干预后存活超过36个月。组织学重新检查显示，这些病例中有3例具有原发性GBM的典型特征，本文将对其进行详细描述。此外，还对相关文献进行了简要综述。
