Sackler School of Medicine, Tel-Aviv University, Israel.
Urology. 2011 May;77(5):1133-6. doi: 10.1016/j.urology.2011.01.009.
Erectile dysfunction (ED) and retinopathy are prevalent in diabetic men. However, the association between ED and diabetic retinopathy (DR) with relation to DR severity levels has never been studied.
For this cross-sectional study, data were obtained prospectively at the retina clinic of a tertiary medical center. The study group included men with proliferative diabetic retinopathy (PDR) or with severe nonproliferative diabetic retinopathy (NPDR). The control group included diabetic men without retinopathy or with mild NPDR. All men had type 2 diabetes mellitus. All men filled in the Sexual Health Inventory for Males questionnaire (SHIM) to detect significant ED. Significant ED was defined as SHIM questionnaire score <17.
The cohort included 102 diabetic men: 64 (62.7%) men in the study group and 38 (37.3%) men in the control group. Mean age for the entire cohort was 64.0 ± 8.2 years, and mean diabetes duration was 14.5 ± 8.9 years. Mean SHIM score for the entire cohort was 11.4 ± 6.5, and 75 (73.5%) men had significant ED. Men in the study group had higher prevalence of significant ED compared with men in the control group (87.5% vs 50.0%; P <.0001), as well as lower mean SHIM questionnaire scores (9.5 ± 5.4 vs 14.7 ± 6.9; P <.0001). Binary logistic regression analysis and linear regression analysis showed that significant ED and SHIM scores, respectively, were associated with DR severity (P = .001 for both), independent of age, diabetes duration, ischemic heart disease, cerebrovascular disease, hypertension, hyperlipidemia, and smoking.
Significant ED is associated with DR severity independent of age, diabetes duration, macrovascular comorbidities, and cardiovascular risk factors.
勃起功能障碍（ED）和视网膜病变在糖尿病男性中很常见。然而，ED 与糖尿病性视网膜病变（DR）之间的关系及其与 DR 严重程度水平的关系从未被研究过。
这项横断面研究的数据是在一家三级医学中心的视网膜诊所前瞻性获得的。研究组包括患有增生性糖尿病视网膜病变（PDR）或严重非增生性糖尿病视网膜病变（NPDR）的男性。对照组包括无视网膜病变或轻度 NPDR 的糖尿病男性。所有男性均患有 2 型糖尿病。所有男性均填写了男性性功能健康问卷（SHIM）以检测是否存在严重的 ED。严重 ED 定义为 SHIM 问卷评分<17。
该队列包括 102 名糖尿病男性：研究组 64 名（62.7%）男性，对照组 38 名（37.3%）男性。整个队列的平均年龄为 64.0±8.2 岁，糖尿病病程平均为 14.5±8.9 年。整个队列的平均 SHIM 评分为 11.4±6.5，75 名（73.5%）男性存在严重 ED。与对照组相比，研究组男性 ED 发生率更高（87.5% vs. 50.0%；P<.0001），SHIM 问卷评分更低（9.5±5.4 vs. 14.7±6.9；P<.0001）。二元逻辑回归分析和线性回归分析表明，严重 ED 和 SHIM 评分分别与 DR 严重程度相关（均为 P=0.001），与年龄、糖尿病病程、缺血性心脏病、脑血管疾病、高血压、高血脂和吸烟无关。
严重 ED 与 DR 严重程度相关，与年龄、糖尿病病程、大血管合并症和心血管危险因素无关。
