pfhrp2 和 pfhrp3 基因联合缺失导致恶性疟原虫快速诊断检测出现假阴性。
Combined deletions of pfhrp2 and pfhrp3 genes result in Plasmodium falciparum malaria false-negative rapid diagnostic test.
机构信息
Laboratoire de Parasitologie, AP-HP, Hôpital Bichat, Paris, France.
出版信息
J Clin Microbiol. 2011 Jul;49(7):2694-6. doi: 10.1128/JCM.00281-11. Epub 2011 May 4.
Abstract
We report a case of misdiagnosis of Plasmodium falciparum malaria from Brazil with negative PfHRP2-based rapid diagnostic tests (RDTs), leading to inappropriate case management. Genetic tests showed the deletion of both pfhrp2 and pfhrp3 genes. The detection of two distinct P. falciparum target antigens is then advisable.
摘要
我们报告了一例来自巴西的恶性疟原虫疟疾病例的误诊，基于 PfHRP2 的快速诊断检测（RDT）呈阴性，导致病例管理不当。基因检测显示 pfhrp2 和 pfhrp3 基因均缺失。因此，建议检测两种不同的恶性疟原虫靶抗原。
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