Department of Virology, Pitié-Salpêtriere Hospital, Paris, France.
J Clin Microbiol. 2011 Jul;49(7):2700-2. doi: 10.1128/JCM.00061-11. Epub 2011 May 4.
The large underestimations of HIV RNA quantification observed in 17 patients with the first version of Cobas TaqMan assay have been successfully corrected in the upgraded version 2.0. In comparison with the Abbott RealTime assay, the mean difference that was 1.18 log(10) copies/ml is now zero. The discrepancies have disappeared.
最初版本的 Cobas TaqMan 检测法对 17 名患者的 HIV RNA 定量结果存在严重低估,该问题在升级版本 2.0 中得到了成功纠正。与 Abbott RealTime 检测法相比,平均差异从之前的 1.18 log(10)拷贝/ml 变为了现在的 0。差异已经消失。