HIV-1 亚型 G 感染者样本中血浆和脑脊液人类免疫缺陷病毒 1 型（HIV-1 RNA）定量错误的临床和耐药后果。
Clinical and resistance consequences of misquantification of plasma and cerebrospinal fluid human immunodeficiency virus type 1 (HIV-1) RNA in samples from an HIV-1 subtype G-infected patient.
机构信息
Department of Virology, Saint-Louis Hospital, 1 avenue Claude Vellefaux, 75010 Paris, France.
出版信息
J Clin Microbiol. 2009 Nov;47(11):3763-4. doi: 10.1128/JCM.00206-09. Epub 2009 Sep 16.
Abstract
Human immunodeficiency virus (HIV) load is the main marker used to monitor antiviral treatment efficacy and resistance. We report a case of underquantification of HIV type 1 (HIV-1) RNA in plasma and cerebrospinal fluid from an HIV-1 subtype G-infected woman, leading to delayed diagnosis of HIV encephalitis and to the emergence of drug resistance.
摘要
人类免疫缺陷病毒 (HIV) 载量是用于监测抗病毒治疗效果和耐药性的主要标志物。我们报告了一例 HIV-1 感染的女性患者血浆和脑脊液中 HIV-1 RNA 检测值偏低的情况，导致 HIV 脑炎的诊断延迟，并出现耐药性。
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