Tsukuma H, Hiyama T, Oshima A, Sobue T, Fujimoto I, Kasugai H, Kojima J, Sasaki Y, Imaoka S, Horiuchi N
Department of Field Research, Center for Adult Diseases, Osaka, Japan.
Int J Cancer. 1990 Feb 15;45(2):231-6. doi: 10.1002/ijc.2910450205.
A case-control study was undertaken to evaluate the roles of hepatitis B virus (HBV), blood transfusion, alcohol drinking and cigarette smoking in the etiology of hepatocellular carcinoma (HCC) in Osaka, Japan. A total of 229 cases and 266 hospital controls were included in our study. The relative risks of HCC obtained after adjustment for age, sex and other important variables were 14.3 (95% confidence interval (CI): 5.7-36.3) for HBsAg positives, 4.3 (95% CI: 1.9-9.6) for blood recipients and 3.2 (95% CI: 2.0-5.1) for heavy drinkers. A statistically significant dose-response relationship was observed between the risk of HCC and total alcohol consumption. The overall risk for HCC was also significantly elevated among smokers; however, there was no consistent dose-response relationship between the risk and cigarette consumption. We conclude that HBV, blood transfusion and excessive alcohol drinking play important roles in the etiology of HCC in Osaka, Japan. Further investigation is needed to clarify the possible etiological role of smoking.
在日本大阪开展了一项病例对照研究，以评估乙型肝炎病毒（HBV）、输血、饮酒和吸烟在肝细胞癌（HCC）病因学中的作用。我们的研究共纳入了229例病例和266例医院对照。在对年龄、性别和其他重要变量进行调整后，HBsAg阳性者发生HCC的相对风险为14.3（95%置信区间（CI）：5.7 - 36.3），接受输血者为4.3（95%CI：1.9 - 9.6），重度饮酒者为3.2（95%CI：2.0 - 5.1）。在HCC风险与总酒精摄入量之间观察到具有统计学意义的剂量反应关系。吸烟者发生HCC的总体风险也显著升高；然而，风险与香烟消费量之间没有一致的剂量反应关系。我们得出结论，HBV、输血和过量饮酒在日本大阪HCC的病因学中起重要作用。需要进一步研究以阐明吸烟可能的病因学作用。
