An antigen chimera of poliovirus induces antibodies against human papillomavirus type 16.
作者信息
Jenkins O, Cason J, Burke K L, Lunney D, Gillen A, Patel D, McCance D J, Almond J W
机构信息
United Medical School, University of Reading, United Kingdom.
出版信息
J Virol. 1990 Mar;64(3):1201-6. doi: 10.1128/JVI.64.3.1201-1206.1990.
Abstract
It has been established that the surface of poliovirus type 1 can be extensively modified to incorporate antigenic domains from other poliovirus serotypes and from unrelated viruses. The fact that the modified (chimeric) viruses exhibit dual antigenicity and immunogenicity led us to explore the possibility of using the Sabin vaccine strain of poliovirus type 1 as a vector for the presentation of antigenic domains from human papillomavirus type 16 (HPV-16), a virus associated with the development of cervical carcinoma. We report here the construction and characterization of a chimeric poliovirus containing a 16-residue sequence derived from the major capsid protein (L1) of HPV-16. This virus chimera stimulated the production in rabbits of antibodies which recognized the HPV-16-derived peptide and an L1 fusion protein synthesized in Escherichia coli and detected HPV-16 in human biopsy material by immunoperoxidase staining. The possibility that poliovirus-HPV chimeras could be used as vaccines against HPV-16 is discussed.
摘要
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本文引用的文献
1
Poliomyelitis vaccines: an appraisal after 25 years.
Compr Ther. 1980 Jan;6(1):6-14.
2
A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.
EMBO J. 1984 May;3(5):1151-7. doi: 10.1002/j.1460-2075.1984.tb01944.x.
3
A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.
Proc Natl Acad Sci U S A. 1983 Jun;80(12):3812-5. doi: 10.1073/pnas.80.12.3812.
4
Neutralization epitopes on poliovirus type 3 particles: an analysis using monoclonal antibodies.
J Gen Virol. 1984 Jan;65 ( Pt 1):197-201. doi: 10.1099/0022-1317-65-1-197.
5
Monoclonal antibodies which block cellular receptors of poliovirus.
Virus Res. 1984;1(3):203-12. doi: 10.1016/0168-1702(84)90039-x.
6
Local antibody response to poliovaccine in the human female genital tract.
J Immunol. 1973 May;110(5):1307-11.
7
Tumour prevention and rejection with recombinant vaccinia.
Nature. 1987;326(6116):878-80. doi: 10.1038/326878a0.
8
Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas.
J Gen Virol. 1987 May;68 ( Pt 5):1351-9. doi: 10.1099/0022-1317-68-5-1351.
9
Histological and immunocytochemical study of cervical intraepithelial neoplasia (CIN) with associated HPV 6 and HPV 16 infections.
J Clin Pathol. 1986 Nov;39(11):1177-80. doi: 10.1136/jcp.39.11.1177.
10
Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein.
Proc Natl Acad Sci U S A. 1986 Jul;83(13):4680-4. doi: 10.1073/pnas.83.13.4680.
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