Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.
J Perinatol. 2012 Jan;32(1):33-8. doi: 10.1038/jp.2011.45. Epub 2011 May 5.
Bronchopulmonary dysplasia (BPD) is a pulmonary disease associated with poor neurodevelopmental and medical outcomes. Patients with BPD are medically fragile, at high risk for complications and require interdisciplinary care. We tested the hypothesis that a chronic care approach for BPD would improve neurodevelopmental outcomes relative to the National Institute of Child and Human Development Neonatal Research Network (NICHD NRN) and reduce medical complications.
Infants were followed as inpatients and outpatients. Bayley developmental exams were carried out at 18-24 months of age and compared with the NICHD NRN report. Finally, rates of readmission (a proxy for medical complications) were compared before and after implementation of the Comprehensive Center for BPD (CCBPD).
Developmental scores obtained in 2007 and 2008 show that 12 and 10% of patients with moderate BPD (n=61) had Bayley Scores <70 for mental and motor indices respectively, whereas corresponding national rates were 35 and 26%. For patients with severe BPD (n=46), 15 and 11% of patients within the CCBPD vs 50 and 42% of national patients scored <70 for mental and motor indices, respectively. Finally, readmission rates dropped from 29% in the year before the implementation of the CCPD (n=269) to 5% thereafter (n=866, P<0.0001).
The encouraging neurodevelopmental outcomes and readmission rates associated with a chronic care approach to BPD suggest these infants may be best served by a comprehensive interdisciplinary approach to care that focuses on neurodevelopment throughout the hospital stay.
支气管肺发育不良(BPD)是一种与神经发育和医疗结果不良相关的肺部疾病。患有 BPD 的患者身体脆弱,并发症风险高,需要多学科护理。我们检验了这样一个假设,即慢性 BPD 护理方法将改善神经发育结果,优于国家儿童健康与人类发展研究所新生儿研究网络(NICHD NRN),并减少医疗并发症。
婴儿作为住院患者和门诊患者接受随访。在 18-24 个月龄时进行贝利发育评估,并与 NICHD NRN 报告进行比较。最后,在实施全面 BPD 中心(CCBPD)前后比较了再入院率(医疗并发症的替代指标)。
2007 年和 2008 年获得的发育评分表明,61 例中度 BPD 患儿(n=61)中有 12%和 10%的患儿在精神和运动指数方面的贝利评分<70,而相应的全国比例为 35%和 26%。对于重度 BPD 患儿(n=46),CCBPD 中有 15%和 11%的患儿,而全国患儿中有 50%和 42%的患儿在精神和运动指数方面的评分<70。最后,再入院率从 CCPD 实施前的 29%(n=269)降至实施后的 5%(n=866,P<0.0001)。
慢性 BPD 护理方法与令人鼓舞的神经发育结果和再入院率相关,这表明这些婴儿可能最好通过一种全面的多学科护理方法来进行治疗,该方法在整个住院期间注重神经发育。