辣木叶片对小鼠砷中毒的保护作用。
Protective effects of Moringa oleifera Lam. leaves against arsenic-induced toxicity in mice.
作者信息
Sheikh Afzal, Yeasmin Fouzia, Agarwal Smita, Rahman Mashiur, Islam Khairul, Hossain Ekhtear, Hossain Shakhawoat, Karim Md Rezaul, Nikkon Farjana, Saud Zahangir Alam, Hossain Khaled
机构信息
Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi-6205, Bangladesh.
出版信息
Asian Pac J Trop Biomed. 2014 May;4(Suppl 1):S353-8. doi: 10.12980/APJTB.4.201414B44.
OBJECTIVE
To evaluate the protective role of leaves of Moringa oleifera (M. oleifera) Lam. against arsenic-induced toxicity in mice.
METHODS
Swiss albino male mice were divided into four groups. The first group was used as non-treated control group while, the second, third, and fourth groups were treated with M. oleifera leaves (50 mg/kg body weight per day), sodium arsenite (10 mg/kg body weight per day) and sodium arsenite plus M. oleifera leaves, respectively. Serum indices related to cardiac, liver and renal functions were analyzed to evaluate the protective effect of Moringa leaves on arsenic-induced effects in mice.
RESULTS
It revealed that food supplementation of M. oleifera leaves abrogated the arsenic-induced elevation of triglyceride, glucose, urea and the activities of alkaline phospatase, aspartate aminotransferase and alanine aminotransferase in serum. M. oleifera leaves also prevented the arsenic-induced perturbation of serum butyryl cholinesterase activity, total cholesterol and high density lipoprotein cholesterol.
CONCLUSIONS
The results indicate that the leaves of M. oleifera may be useful in reducing the effects of arsenic-induced toxicity.
目的
评估辣木叶片对小鼠砷中毒的保护作用。
方法
将瑞士白化雄性小鼠分为四组。第一组作为未处理的对照组，而第二、第三和第四组分别用辣木叶片（每天50毫克/千克体重）、亚砷酸钠（每天10毫克/千克体重）和亚砷酸钠加辣木叶片进行处理。分析与心脏、肝脏和肾脏功能相关的血清指标，以评估辣木叶片对小鼠砷诱导效应的保护作用。
结果
结果显示，补充辣木叶片可消除砷诱导的血清甘油三酯、葡萄糖、尿素以及碱性磷酸酶、天冬氨酸转氨酶和丙氨酸转氨酶活性的升高。辣木叶片还可防止砷诱导的血清丁酰胆碱酯酶活性、总胆固醇和高密度脂蛋白胆固醇的紊乱。
结论
结果表明，辣木叶片可能有助于减轻砷中毒的影响。
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