Hôtel-Dieu Hospital, Neurology Service, Neurobiology Laboratory, Montreal, Quebec, H2W IT8 (Canada) and University of Montreal, Departments of Medicine and Psychology, Montreal, Quebec (Canada).
Restor Neurol Neurosci. 1993 Jan 1;5(5):367-70. doi: 10.3233/RNN-1993-55607.
The effects of amantadine and ketamine were compared to a placebo in a coat-hanger test on lurcher mutant mice. This test measures motor coordination and is dependent on cerebellar functioning. Both drugs improved motor coordination of the cerebellar mutants in that the time taken to reach the side-bar according to a 2 paw criterion was decreased during the drugged condition in comparison to the non-drugged condition. This result indicates that NMDA receptor antagonists may improve motor coordination in animals with cerebellar disease.
在一项针对猎犬突变小鼠的衣架测试中，比较了金刚烷胺和氯胺酮与安慰剂的效果。该测试测量运动协调能力，取决于小脑的功能。这两种药物都改善了小脑突变体的运动协调能力，即在药物处理条件下，根据 2 爪标准到达侧杆的时间与非药物处理条件相比缩短了。这一结果表明，NMDA 受体拮抗剂可能改善小脑疾病动物的运动协调能力。
