Griebel P J, Ohmann H B, Lawman M J, Babiuk L A
Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
J Gen Virol. 1990 Feb;71 ( Pt 2):369-77. doi: 10.1099/0022-1317-71-2-369.
The interaction between activated bovine T lymphocytes (BTLs) and bovine herpesvirus type 1 (BHV-1) was investigated. BHV-1 infection of BTLs reduced the amplitude of recombinant bovine interleukin 2-induced proliferative responses. This decreased proliferation was caused by a virus-induced lymphocytolysis which was dependent on viable virus and was not inhibited by recombinant bovine interferon-alpha I1. Furthermore, lymphocytolysis was not associated with virus replication or with the synthesis of detectable levels of viral proteins. Electron microscopic examination of virus-infected cells revealed that lymphocytolysis was characterized by early nuclear disintegration resembling apoptosis. These observations suggest that activated T cells, localized at the site of BHV-1 infection, may be susceptible to virus-induced cytolysis.
研究了活化的牛T淋巴细胞（BTL）与牛1型疱疹病毒（BHV-1）之间的相互作用。BHV-1感染BTL降低了重组牛白细胞介素2诱导的增殖反应幅度。这种增殖减少是由病毒诱导的淋巴细胞溶解引起的，该溶解依赖于活病毒，且不受重组牛α干扰素I1抑制。此外，淋巴细胞溶解与病毒复制或可检测水平的病毒蛋白合成无关。对病毒感染细胞的电子显微镜检查显示，淋巴细胞溶解的特征是早期核崩解，类似于细胞凋亡。这些观察结果表明，位于BHV-1感染部位的活化T细胞可能易受病毒诱导的细胞溶解作用影响。
