Frösner G, Willers H, Müller R, Schenzle D, Deinhardt F, Höpken W
Infection. 1978;6(6):259-60. doi: 10.1007/BF01641983.
The hypothesis of a decline in the incidence of hepatitis A infections in Germany in recent decades was confirmed by determining the prevalence of hepatitis A antibody (anti-HAV) in sera collected in 1965 and in 1975 under the same conditions in North Germany. The prevalence of anti-HAV correlated with the year of birth and was independent of the time of serum sampling. The force of infection fell from 0.04 in 1945 to 0.005 in 1965 as judged from a catalytic epidemic model with a sigmoidal decrease.
通过测定1965年和1975年在德国北部相同条件下采集的血清中甲肝抗体（抗-HAV）的流行率，证实了近几十年来德国甲型肝炎感染发病率下降的假设。抗-HAV的流行率与出生年份相关，且与血清采样时间无关。根据具有S形下降的催化流行模型判断，感染强度从1945年的0.04降至1965年的0.005。
