Department of Clinical Sciences Malmö, Ophthalmology, Skåne University Hospital Malmö, Lund University, Malmö, Sweden.
Diabetes Care. 2011 Jun;34(6):1318-9. doi: 10.2337/dc10-2308. Epub 2011 May 11.
To report the incidence of sight-threatening vascular lesions in type 2 diabetic subjects without retinopathy after adopting a 3-year interval screening program.
In all, 1,691 type 2 diabetic subjects with no detectable retinopathy in two 50° red-free fundus photographs were scheduled for follow-up with photography 3 years later. Age at diabetes diagnosis was 60 ± 12 years, and known duration of diabetes was 6 ± 6 years. Treatment consisted of diet only (26%), oral agents (54%), and oral agents and/or insulin (20%). Glycated hemoglobin A(1c) was 6.4 ± 1.5%.
Of the 1,322 subjects available for follow-up, 73% were still without retinopathy after 3 years, and 28% had developed mild or moderate retinopathy, but none developed severe nonproliferative or proliferative retinopathy. Macular edema requiring laser coagulation occurred in only one eye.
Three-year retinal screening intervals can be recommended in subjects with mild type 2 diabetes and no retinopathy.
报告在采用 3 年间隔筛查方案后，无视网膜病变的 2 型糖尿病患者中出现威胁视力的血管病变的发生率。
共有 1691 例 2 型糖尿病患者，在两次 50°无赤红色眼底照片中均未发现可检测到的视网膜病变，他们被安排在 3 年后进行随访，并进行摄影检查。糖尿病诊断时的年龄为 60 ± 12 岁，已知糖尿病病程为 6 ± 6 年。治疗包括饮食治疗（26%）、口服药物（54%）和口服药物和/或胰岛素（20%）。糖化血红蛋白 A1c 为 6.4 ± 1.5%。
在 1322 例可进行随访的患者中，73%在 3 年后仍无视网膜病变，28%出现轻度或中度视网膜病变，但均未出现严重的非增生性或增生性视网膜病变。仅有一只眼发生需要激光凝固治疗的黄斑水肿。
对于轻度 2 型糖尿病且无视网膜病变的患者，可以推荐 3 年的视网膜筛查间隔。
