念珠菌属在控制良好的2型糖尿病义齿性口炎患者中的患病率。
Candida spp. prevalence in well controlled type 2 diabetic patients with denture stomatitis.
作者信息
Sanitá Paula Volpato, Pavarina Ana Cláudia, Giampaolo Eunice Teresinha, Silva Mariana Montenegro, Mima Ewerton Garcia de Oliveira, Ribeiro Daniela Garcia, Vergani Carlos Eduardo
机构信息
Araraquara Dental School, UNESP - Univ Estadual Paulista, Araraquara, São Paulo, Brazil.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Jun;111(6):726-33. doi: 10.1016/j.tripleo.2011.02.033.
OBJECTIVE
The aim of this study was to compare the prevalence of Candida spp. in diabetics and nondiabetics with and without denture stomatitis (DS).
STUDY DESIGN
Mycologic samples were taken from the dentures of 90 healthy subjects (control group [CG]), 80 denture stomatitis nondiabetics (DSND), and 40 denture stomatitis diabetics (DSD; well controlled type 2) for identification of Candida spp. Results were analyzed by Fisher exact test, Bonferroni-corrected confidence interval, and χ(2) test (α = .05).
RESULTS
Candida albicans was the predominant species isolated (81.9%; P < .016), with C. tropicalis and C. glabrata demonstrating similar prevalence (15.71% and 15.24%, respectively). The prevalence of C. albicans and C. tropicalis in the DS groups were significantly higher (P < .01) than in the CG. The prevalence of C. tropicalis significantly increased with the highest degree of inflammation (P < .05).
CONCLUSIONS
The prevalence of Candida spp. was similar between diabetic and nondiabetic patients with DS. Candida tropicalis may play a role in the progression of DS.
目的
本研究旨在比较念珠菌属在患有和未患义齿性口炎（DS）的糖尿病患者和非糖尿病患者中的患病率。
研究设计
从90名健康受试者（对照组[CG]）、80名患义齿性口炎的非糖尿病患者（DSND）和40名患义齿性口炎的糖尿病患者（DSD；2型糖尿病控制良好）的义齿上采集真菌样本，以鉴定念珠菌属。结果采用Fisher精确检验、Bonferroni校正置信区间和χ²检验进行分析（α = 0.05）。
结果
白色念珠菌是分离出的主要菌种（81.9%；P < 0.016），热带念珠菌和光滑念珠菌的患病率相似（分别为15.71%和15.24%）。DS组中白色念珠菌和热带念珠菌的患病率显著高于CG组（P < 0.01）。热带念珠菌的患病率随炎症程度的加重而显著增加（P < 0.05）。
结论
患有DS的糖尿病患者和非糖尿病患者中念珠菌属的患病率相似。热带念珠菌可能在DS的进展中起作用。
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