反转子，一类结构和功能相关的遗传元件，包括线性DNA质粒、转座元件和腺病毒型病毒的基因组。
Invertrons, a class of structurally and functionally related genetic elements that includes linear DNA plasmids, transposable elements, and genomes of adeno-type viruses.
作者信息
Sakaguchi K
机构信息
Nihon Shokuhin Kako Laboratories, Tokyo, Japan.
出版信息
Microbiol Rev. 1990 Mar;54(1):66-74. doi: 10.1128/mr.54.1.66-74.1990.
Abstract
Invertrons are genetic elements composed of DNA with inverted terminal repeats at both ends, covalently bonded to terminal proteins involved in the initiation of DNA replication at both their 5' termini when they exist in the cytoplasm of their host in free form. They function as viruses, linear DNA plasmids, transposable elements, and sometimes combinations of two of these properties. They differ from retroviruses and related retro-type transposons which have direct repeats on both their genomic ends and exploit RNA intermediates for replication of their DNA. A model for replication and integration of invertrons is presented, as well as a model for transposition of transposable elements.
摘要
反转子是由两端带有反向末端重复序列的DNA组成的遗传元件，当它们以游离形式存在于宿主细胞质中时，在其5'末端与参与DNA复制起始的末端蛋白共价结合。它们具有病毒、线性DNA质粒、转座元件的功能，有时还具有其中两种特性的组合。它们不同于逆转录病毒和相关的逆转录型转座子，后者在其基因组两端都有正向重复序列，并利用RNA中间体进行DNA复制。本文提出了反转子的复制和整合模型，以及转座元件的转座模型。
相似文献
1
Invertrons, a class of structurally and functionally related genetic elements that includes linear DNA plasmids, transposable elements, and genomes of adeno-type viruses.反转子，一类结构和功能相关的遗传元件，包括线性DNA质粒、转座元件和腺病毒型病毒的基因组。
Microbiol Rev. 1990 Mar;54(1):66-74. doi: 10.1128/mr.54.1.66-74.1990.
2
Absence of direct repeats flanking transposons resulting from intramolecular transposition.由于分子内转座导致转座子侧翼不存在直接重复序列。
Gene. 1984 Apr;28(1):103-12. doi: 10.1016/0378-1119(84)90092-1.
3
The presence of the transposable element ISBsu2 from a cryptic plasmid in chromosomes of some Bacillus subtilis strains.某些枯草芽孢杆菌菌株染色体中来自隐蔽质粒的转座元件ISBsu2的存在。
Dokl Biochem Biophys. 2002 Sep-Oct;386:275-7. doi: 10.1023/a:1020767829745.
4
Recombination between short repeated sequences is more frequent in plasmids than in the chromosome of Bacillus subtilis.在枯草芽孢杆菌中，短重复序列之间的重组在质粒中比在染色体中更频繁。
Mol Gen Genet. 1987 Nov;210(1):116-21. doi: 10.1007/BF00337766.
5
On two transposable elements from Bacillus stearothermophilus.关于嗜热脂肪芽孢杆菌的两个转座元件。
Plasmid. 1993 Jan;29(1):1-9. doi: 10.1006/plas.1993.1001.
6
Excision of transposon Tn917 in Bacillus subtilis.
J Basic Microbiol. 1990;30(6):387-92. doi: 10.1002/jobm.3620300602.
7
Plasmid deletion formation between short direct repeats in Bacillus subtilis is stimulated by single-stranded rolling-circle replication intermediates.枯草芽孢杆菌中短直接重复序列间的质粒缺失形成受单链滚环复制中间体的刺激。
Mol Gen Genet. 1991 Apr;226(1-2):88-96. doi: 10.1007/BF00273591.
8
Mutational analysis of the inverted repeats of Tn3.Tn3反向重复序列的突变分析。
J Mol Biol. 1990 Jun 20;213(4):671-6. doi: 10.1016/S0022-2836(05)80254-2.
9
Tn10-derived transposons active in Bacillus subtilis.源自Tn10且在枯草芽孢杆菌中具有活性的转座子。
J Bacteriol. 1990 Dec;172(12):6736-40. doi: 10.1128/jb.172.12.6736-6740.1990.
10
Complete sequence determination combined with analysis of transposition/site-specific recombination events to explain genetic organization of IncP-7 TOL plasmid pWW53 and related mobile genetic elements.完整序列测定结合转座/位点特异性重组事件分析，以解释IncP-7 TOL质粒pWW53及相关可移动遗传元件的基因组织。
J Mol Biol. 2007 May 25;369(1):11-26. doi: 10.1016/j.jmb.2007.02.098. Epub 2007 Mar 14.
引用本文的文献
1
Linear Plasmids in Micrococcus: Insights Into a Common Ancestor and Transfer by Conjugation.微球菌中的线性质粒：对共同祖先及接合转移的见解
Environ Microbiol. 2025 Jan;27(1):e70020. doi: 10.1111/1462-2920.70020.
2
Genetic Diversity in the mtDNA of .. 的 mtDNA 中的遗传多样性
Genes (Basel). 2023 Mar 2;14(3):628. doi: 10.3390/genes14030628.
3
Novel Multidrug-Resistant Enterococcal Mobile Linear Plasmid pELF1 Encoding and Gene Clusters From a Japanese Vancomycin-Resistant Enterococci Isolate.新型多重耐药肠球菌移动线性质粒pELF1，来自一株日本耐万古霉素肠球菌分离株的编码及基因簇
Front Microbiol. 2019 Nov 13;10:2568. doi: 10.3389/fmicb.2019.02568. eCollection 2019.
4
Molecular Characterization of Plasmids Harbored by Actinomycetes Isolated From the Great Salt Plains of Oklahoma Using PFGE and Next Generation Whole Genome Sequencing.利用脉冲场凝胶电泳（PFGE）和新一代全基因组测序对从俄克拉荷马大盐原分离出的放线菌携带的质粒进行分子特征分析。
Front Microbiol. 2018 Sep 28;9:2282. doi: 10.3389/fmicb.2018.02282. eCollection 2018.
5
The Importance of ncRNAs as Epigenetic Mechanisms in Phenotypic Variation and Organic Evolution.非编码RNA作为表型变异和生物进化中表观遗传机制的重要性。
Front Microbiol. 2017 Dec 22;8:2483. doi: 10.3389/fmicb.2017.02483. eCollection 2017.
6
Moniliophthora roreri, causal agent of cacao frosty pod rot.可可霜疫霉，可可霜疫病菌。
Mol Plant Pathol. 2018 Jul;19(7):1580-1594. doi: 10.1111/mpp.12648. Epub 2018 Feb 15.
7
Animal Mitochondrial DNA as We Do Not Know It: mt-Genome Organization and Evolution in Nonbilaterian Lineages.我们所未知的动物线粒体DNA：非两侧对称动物谱系中的线粒体基因组组织与进化
Genome Biol Evol. 2016 Sep 26;8(9):2896-2913. doi: 10.1093/gbe/evw195.
8
Mitochondrial genome rearrangements in glomus species triggered by homologous recombination between distinct mtDNA haplotypes.动基体基因组重排在 Glomus 种中由不同 mtDNA 单倍型间的同源重组触发。
Genome Biol Evol. 2013;5(9):1628-43. doi: 10.1093/gbe/evt120.
9
Strikingly bacteria-like and gene-rich mitochondrial genomes throughout jakobid protists.Jakobid 原生动物中富含基因且具有细菌样特征的线粒体基因组。
Genome Biol Evol. 2013;5(2):418-38. doi: 10.1093/gbe/evt008.
10
First description of natural and experimental conjugation between Mycobacteria mediated by a linear plasmid.首次描述了线性质粒介导的分枝杆菌自然和实验性接合。
PLoS One. 2012;7(1):e29884. doi: 10.1371/journal.pone.0029884. Epub 2012 Jan 3.
本文引用的文献
1
Nucleotide sequence of the S-2 mitochondrial DNA from the S cytoplasm of maize.玉米 S 细胞质中 S-2 线粒体 DNA 的核苷酸序列。
Proc Natl Acad Sci U S A. 1983 Jul;80(13):4055-9. doi: 10.1073/pnas.80.13.4055.
2
Unique DNA associated with mitochondria in the "S"-type cytoplasm of male-sterile maize.与雄性不育玉米“S”型细胞质中线粒体相关的独特DNA。
Proc Natl Acad Sci U S A. 1977 Jul;74(7):2904-8. doi: 10.1073/pnas.74.7.2904.
3
The Spm (En) transposable element controls the excision of a 2-kb DNA insert at the wx allele of Zea mays.Spm（En）转座元件控制着玉米 wx 等位基因上 2kbDNA 插入片段的切除。
EMBO J. 1984 May;3(5):1021-8. doi: 10.1002/j.1460-2075.1984.tb01922.x.
4
The 17-kb Tam1 element of Antirrhinum majus induces a 3-bp duplication upon integration into the chalcone synthase gene.金鱼草的 17-kb Tam1 元件在整合到查尔酮合酶基因时会引起 3-bp 的重复。
EMBO J. 1984 May;3(5):1015-9. doi: 10.1002/j.1460-2075.1984.tb01921.x.
5
Chromosome organization and genic expression.染色体组织与基因表达。
Cold Spring Harb Symp Quant Biol. 1951;16:13-47. doi: 10.1101/sqb.1951.016.01.004.
6
Integration of adenovirus type 2 DNA at a limited number of cellular sites in productively infected cells.2型腺病毒DNA在高效感染细胞中的有限数量细胞位点处整合。
J Virol. 1981 Mar;37(3):887-92. doi: 10.1128/JVI.37.3.887-892.1981.
7
Eukaryotic DNA replication: viral and plasmid model systems.真核生物DNA复制：病毒和质粒模型系统
Annu Rev Biochem. 1982;51:901-34. doi: 10.1146/annurev.bi.51.070182.004345.
8
Transformation of Saccharomyces cerevisiae with linear DNA killer plasmids from Kluyveromyces lactis.用来自乳酸克鲁维酵母的线性DNA杀伤质粒转化酿酒酵母。
J Bacteriol. 1982 Jul;151(1):462-4. doi: 10.1128/jb.151.1.462-464.1982.
9
Inverted terminal repetitions of the two linear DNA associated with the killer character of the yeast Kluyveromyces lactis.与乳酸克鲁维酵母杀伤特性相关的两条线性DNA的反向末端重复序列。
Nucleic Acids Res. 1983 Aug 11;11(15):5037-44. doi: 10.1093/nar/11.15.5037.
10
Protein p3 is linked to the DNA of phage phi 29 through a phosphoester bond between serine and 5'-dAMP.蛋白质p3通过丝氨酸与5'-二磷酸腺苷之间的磷酸酯键与噬菌体φ29的DNA相连。
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6425-8. doi: 10.1073/pnas.77.11.6425.
Zotero 插件