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反转子，一类结构和功能相关的遗传元件，包括线性DNA质粒、转座元件和腺病毒型病毒的基因组。

Invertrons, a class of structurally and functionally related genetic elements that includes linear DNA plasmids, transposable elements, and genomes of adeno-type viruses.

作者信息

Sakaguchi K

机构信息

Nihon Shokuhin Kako Laboratories, Tokyo, Japan.

出版信息

Microbiol Rev. 1990 Mar;54(1):66-74. doi: 10.1128/mr.54.1.66-74.1990.

DOI:10.1128/mr.54.1.66-74.1990
PMID:2157134
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC372759/
Abstract

Invertrons are genetic elements composed of DNA with inverted terminal repeats at both ends, covalently bonded to terminal proteins involved in the initiation of DNA replication at both their 5' termini when they exist in the cytoplasm of their host in free form. They function as viruses, linear DNA plasmids, transposable elements, and sometimes combinations of two of these properties. They differ from retroviruses and related retro-type transposons which have direct repeats on both their genomic ends and exploit RNA intermediates for replication of their DNA. A model for replication and integration of invertrons is presented, as well as a model for transposition of transposable elements.

摘要

反转子是由两端带有反向末端重复序列的DNA组成的遗传元件，当它们以游离形式存在于宿主细胞质中时，在其5'末端与参与DNA复制起始的末端蛋白共价结合。它们具有病毒、线性DNA质粒、转座元件的功能，有时还具有其中两种特性的组合。它们不同于逆转录病毒和相关的逆转录型转座子，后者在其基因组两端都有正向重复序列，并利用RNA中间体进行DNA复制。本文提出了反转子的复制和整合模型，以及转座元件的转座模型。

相似文献

1
Invertrons, a class of structurally and functionally related genetic elements that includes linear DNA plasmids, transposable elements, and genomes of adeno-type viruses.反转子，一类结构和功能相关的遗传元件，包括线性DNA质粒、转座元件和腺病毒型病毒的基因组。
Microbiol Rev. 1990 Mar;54(1):66-74. doi: 10.1128/mr.54.1.66-74.1990.
2
Absence of direct repeats flanking transposons resulting from intramolecular transposition.由于分子内转座导致转座子侧翼不存在直接重复序列。
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本文引用的文献

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Nucleotide sequence of the S-2 mitochondrial DNA from the S cytoplasm of maize.玉米 S 细胞质中 S-2 线粒体 DNA 的核苷酸序列。
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The Spm (En) transposable element controls the excision of a 2-kb DNA insert at the wx allele of Zea mays.Spm（En）转座元件控制着玉米 wx 等位基因上 2kbDNA 插入片段的切除。
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The 17-kb Tam1 element of Antirrhinum majus induces a 3-bp duplication upon integration into the chalcone synthase gene.金鱼草的 17-kb Tam1 元件在整合到查尔酮合酶基因时会引起 3-bp 的重复。
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Chromosome organization and genic expression.染色体组织与基因表达。
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Transformation of Saccharomyces cerevisiae with linear DNA killer plasmids from Kluyveromyces lactis.用来自乳酸克鲁维酵母的线性DNA杀伤质粒转化酿酒酵母。
J Bacteriol. 1982 Jul;151(1):462-4. doi: 10.1128/jb.151.1.462-464.1982.
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Inverted terminal repetitions of the two linear DNA associated with the killer character of the yeast Kluyveromyces lactis.与乳酸克鲁维酵母杀伤特性相关的两条线性DNA的反向末端重复序列。
Nucleic Acids Res. 1983 Aug 11;11(15):5037-44. doi: 10.1093/nar/11.15.5037.
10
Protein p3 is linked to the DNA of phage phi 29 through a phosphoester bond between serine and 5'-dAMP.蛋白质p3通过丝氨酸与5'-二磷酸腺苷之间的磷酸酯键与噬菌体φ29的DNA相连。
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6425-8. doi: 10.1073/pnas.77.11.6425.