Novosad Billy D, Callegan Michelle C
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Expert Rev Ophthalmol. 2010 Oct;5(5):689-698. doi: 10.1586/eop.10.52.
Endophthalmitis is an infection and inflammation of the interior of the eye that can result in significant vision loss. This infection occurs as a result of the seeding of organisms into the interior of the eye following surgery (postoperative), trauma (post-traumatic) or an infection in another site in the body (endogenous). The general rate of endophthalmitis has remained steady over the past several years. However, the increased use of intraocular injections to treat various degenerative and inflammatory ocular diseases, in addition to the already large and growing number of invasive ocular surgeries, may increase the opportunities in which organisms can gain access to the eye. In most cases of endophthalmitis, useful vision can be retained if proper treatment is instituted. However, in severe cases of bacterial endophthalmitis, blindness often occurs despite treatment. This article summarizes information on endophthalmitis epidemiology, treatment issues and current regimens, and recent experimental and clinical efforts to improve the outcome of severe and blinding forms of bacterial endophthalmitis.
眼内炎是一种眼内的感染和炎症，可导致严重的视力丧失。这种感染是在手术（术后）、外伤（创伤后）或身体其他部位感染（内源性）后，微生物进入眼内所致。在过去几年中，眼内炎的总体发生率一直保持稳定。然而，除了已经大量且不断增加的侵入性眼科手术外，用于治疗各种退行性和炎症性眼病的眼内注射的使用增加，可能会增加微生物进入眼睛的机会。在大多数眼内炎病例中，如果进行适当治疗，可以保留有用的视力。然而，在严重的细菌性眼内炎病例中，尽管进行了治疗，失明仍经常发生。本文总结了有关眼内炎流行病学、治疗问题和当前治疗方案的信息，以及最近为改善严重和致盲性细菌性眼内炎的治疗结果所做的实验和临床努力。
