College of Pharmacy, University of Minnesota, 308 Harvard Street SE, Minneapolis, MN 55455, USA.
J Med Econ. 2011;14(3):367-80. doi: 10.3111/13696998.2011.583303. Epub 2011 May 17.
The aims of this paper are to report on the prevalence, correlates and treatment of pain in the adult Spanish population. The analysis also explores the association between the experience of pain and health-related quality of life (HRQoL), employment and productivity, and healthcare resource utilization.
Data are from the Internet-based, 2010 National Health and Wellness Survey (NHWS) Spain. The sample was weighted by age and sex to correspond to the 2010 adult Spanish population. All respondents to the NHWS reported on socio-demographic and economic characteristics, medication adherence and major health conditions. They also reported on their HRQoL (the SF-12), their employment status and workplace productivity experience (WPAI instrument) and their healthcare resource utilization. Persons reporting experiencing pain gave details on conditions causing pain, prescription and over the counter (OTC) medication utilization, duration of utilization and satisfaction with medications. A supplementary analysis evaluated the population prevalence of pain for the five most populous Spanish autonomous communities (regions).
An estimated 6.10 million (17.25%) of the adult population of Spain reported experiencing pain in the last month. Of these 11.69% experienced severe pain, 64.17% moderate pain and 24.14% mild pain. Daily pain was experienced by 6.95% of the population The major conditions causing pain are back pain (60.53%) followed by joint pain (40.21%). Sleep difficulties (42.24%) and anxiety (40.62%) were most commonly cited as comorbidities. Prescription medication utilization was most important in the severe and moderate pain categories, with 71.62% reporting they were satisfied with their prescription pain medications. Adherence to pain medications was high with an overall Morisky score of 0.99 (range 0-4). Pain had a major negative effect on labor force participation for those reporting moderate and severe pain with a participation rate of only 42.62% for those with severe pain. Pain was associated with substantial health-related quality of life deficits as measured by the physical and mental score components of the SF-12. In the case of SF-6D utilities, the utility score for the pain population was markedly below that for the no-pain population (0.65 vs. 0.75; p < 0.05).The experience of pain also negatively impacted rates of absenteeism and presenteeism, as well as being associated with greater healthcare resource utilization. Finally, for the five most populous autonomous communities of Spain estimated pain prevalence ranged from 14.80% for Madrid to 18.79% for Comunidad Valenciana. The are a number of limitations which should be noted. First, this is an internet-based sample study and the respondent population may not be representative of the Spanish adult population. Second, respondents are asked to report their experience of pain with no independent clinical conformation. Finally, while a number of obvious acute pain categories are excluded, there is no attempt to arbitrarily define a chronic pain population or to identify pain categories such as neuropathic pain.
The experience of pain represents a substantial burden on both individuals and the Spanish economy. The experience of pain is associated with a substantial reduction in both the PCS component of the SF-12 and SF-6D absolute utilities--most notably in respect of severe pain. The experience of pain is also associated, not only with reduced labor force participation and increased absenteeism and presenteeism, but with substantially higher patterns of healthcare resource utilization.
本文旨在报告西班牙成年人中疼痛的流行率、相关因素和治疗情况。分析还探讨了疼痛体验与健康相关生活质量(HRQoL)、就业和生产力以及医疗保健资源利用之间的关系。
数据来自基于互联网的 2010 年国家健康和健康调查(NHWS)西班牙。该样本按年龄和性别加权,以对应 2010 年西班牙成年人口。所有参加 NHWS 的受访者都报告了社会人口和经济特征、药物依从性以及主要健康状况。他们还报告了他们的 HRQoL(SF-12)、他们的就业状况和工作场所生产力体验(WPAI 工具)以及他们的医疗保健资源利用情况。报告有疼痛经历的人详细说明了导致疼痛的情况、处方和非处方(OTC)药物的使用情况、使用时间以及对药物的满意度。一项补充分析评估了西班牙五个人口最多的自治区(地区)的疼痛流行率。
据估计,西班牙成年人中有 610 万人(17.25%)在过去一个月经历过疼痛。其中 11.69%的人经历过严重疼痛,64.17%的人经历过中度疼痛,24.14%的人经历过轻度疼痛。每天都有 6.95%的人感到疼痛。主要导致疼痛的疾病是背痛(60.53%),其次是关节痛(40.21%)。睡眠困难(42.24%)和焦虑(40.62%)是最常见的合并症。在严重和中度疼痛类别中,处方药物的使用最为重要,71.62%的人报告他们对处方止痛药感到满意。疼痛药物的依从性很高,总体莫斯基评分得分为 0.99(范围 0-4)。对于报告中度和重度疼痛的人来说,疼痛对劳动力参与率有很大的负面影响,只有 42.62%的重度疼痛患者参与工作。疼痛与 SF-12 的身体和心理评分成分所衡量的健康相关生活质量缺陷有很大关系。在 SF-6D 效用方面,疼痛人群的效用评分明显低于无疼痛人群(0.65 与 0.75;p < 0.05)。疼痛体验也会降低旷工率和病休率,并与更多的医疗保健资源利用有关。最后,对于西班牙五个人口最多的自治区,估计的疼痛流行率从马德里的 14.80%到瓦伦西亚社区的 18.79%不等。需要注意的是,本研究存在一些局限性。首先,这是一项基于互联网的样本研究,应答人群可能无法代表西班牙成年人口。其次,受访者被要求报告他们的疼痛经历,但没有独立的临床确认。最后,虽然排除了一些明显的急性疼痛类别,但并没有试图任意定义慢性疼痛人群或确定神经病理性疼痛等疼痛类别。
疼痛体验给个人和西班牙经济都带来了巨大的负担。疼痛体验与 SF-12 的 PCS 成分和 SF-6D 绝对效用显著降低有关,尤其是在严重疼痛方面。疼痛体验不仅与劳动力参与率降低、旷工和病休率增加有关,而且还与医疗保健资源利用模式显著增加有关。