伐昔洛韦治疗单纯疱疹脑炎。
Valacyclovir for herpes simplex encephalitis.
机构信息
Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
出版信息
Antimicrob Agents Chemother. 2011 Jul;55(7):3624-6. doi: 10.1128/AAC.01023-10. Epub 2011 May 16.
Abstract
The recommended treatment for herpes simplex encephalitis (HSE) remains intravenous acyclovir. In resource-poor countries, however, intravenous formulations are usually unavailable or unaffordable. We report the penetration of acyclovir into the cerebrospinal fluid (CSF) in patients with HSE, treated with the oral prodrug valacyclovir at 1,000 mg three times daily. The oral therapy achieved adequate acyclovir concentrations in the CSF and may be an acceptable early treatment for suspected HSE in resource-limited settings.
摘要
推荐用于单纯疱疹脑炎（HSE）的治疗方法仍然是静脉注射阿昔洛韦。然而，在资源匮乏的国家，静脉制剂通常无法获得或负担不起。我们报告了口服前药伐昔洛韦，每天三次，每次 1000 毫克，用于治疗 HSE 患者时，阿昔洛韦在脑脊液（CSF）中的渗透情况。这种口服治疗方法可使 CSF 中的阿昔洛韦浓度达到足够水平，在资源有限的情况下，可能是疑似 HSE 的一种可接受的早期治疗方法。
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