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伐昔洛韦治疗单纯疱疹脑炎。

Valacyclovir for herpes simplex encephalitis.

机构信息

Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

出版信息

Antimicrob Agents Chemother. 2011 Jul;55(7):3624-6. doi: 10.1128/AAC.01023-10. Epub 2011 May 16.

DOI:10.1128/AAC.01023-10
PMID:21576427
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3122427/
Abstract

The recommended treatment for herpes simplex encephalitis (HSE) remains intravenous acyclovir. In resource-poor countries, however, intravenous formulations are usually unavailable or unaffordable. We report the penetration of acyclovir into the cerebrospinal fluid (CSF) in patients with HSE, treated with the oral prodrug valacyclovir at 1,000 mg three times daily. The oral therapy achieved adequate acyclovir concentrations in the CSF and may be an acceptable early treatment for suspected HSE in resource-limited settings.

摘要

推荐用于单纯疱疹脑炎（HSE）的治疗方法仍然是静脉注射阿昔洛韦。然而，在资源匮乏的国家，静脉制剂通常无法获得或负担不起。我们报告了口服前药伐昔洛韦，每天三次，每次 1000 毫克，用于治疗 HSE 患者时，阿昔洛韦在脑脊液（CSF）中的渗透情况。这种口服治疗方法可使 CSF 中的阿昔洛韦浓度达到足够水平，在资源有限的情况下，可能是疑似 HSE 的一种可接受的早期治疗方法。

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本文引用的文献

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Viral etiology of encephalitis in children in southern Vietnam: results of a one-year prospective descriptive study.越南南部儿童脑炎的病毒病因：一项为期一年的前瞻性描述性研究结果。
PLoS Negl Trop Dis. 2010 Oct 26;4(10):e854. doi: 10.1371/journal.pntd.0000854.
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Pharmacokinetics of acyclovir and its metabolites in cerebrospinal fluid and systemic circulation after administration of high-dose valacyclovir in subjects with normal and impaired renal function.肾功能正常和受损受试者中给予高剂量伐昔洛韦后脑脊液和全身循环中阿昔洛韦及其代谢物的药代动力学。
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Acyclovir levels in serum and cerebrospinal fluid after oral administration of valacyclovir.口服伐昔洛韦后血清和脑脊液中的阿昔洛韦水平。
Antimicrob Agents Chemother. 2003 Aug;47(8):2438-41. doi: 10.1128/AAC.47.8.2438-2441.2003.
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Determination of acyclovir in plasma by solid-phase extraction and column liquid chromatography.通过固相萃取和柱液相色谱法测定血浆中的阿昔洛韦。
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Determination of acyclovir and its metabolite 9-carboxymethoxymethylguanine in serum and urine using solid-phase extraction and high-performance liquid chromatography.采用固相萃取和高效液相色谱法测定血清和尿液中的阿昔洛韦及其代谢产物9-羧基甲氧基甲基鸟嘌呤。
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