Irving W L, Ratnamohan V M, Hueston L C, Chapman J R, Cunningham A L
Department of Infectious Diseases, Westmead Hospital, Sydney, Australia.
J Infect Dis. 1990 May;161(5):910-6. doi: 10.1093/infdis/161.5.910.
The frequency of high (greater than 256) IgG anti-human herpesvirus type 6 (HHV-6) titers in sera known to be positive for IgM anti-cytomegalovirus (CMV) or IgM anti-Epstein Barr virus (EBV) was significantly greater than in sera from healthy controls or from a group of ill patients who were CMV and EBV IgM-negative (15/25 and 17/25 vs. 1/25 and 2/25, respectively, P less than .001). There was serologic evidence of simultaneous HHV-6 infection or reactivation (a rise in IgG anti-HHV-6 titer or the presence of IgM anti-HHV-6) in sera from 14 of 17 primary CMV infections. In 5 of the 10 patients with concurrent rises in IgG titers to both viruses, the rise in IgG anti-HHV-6 preceded that of IgG anti-CMV. Complete removal of IgG anti-CMV reactivity from 5 sera from patients who had a primary CMV infection with a rise in IgG anti-HHV-6 titer had no effect on the IgG anti-HHV-6 titer of those sera, demonstrating that the rise in HHV-6 IgG titer was not a consequence of anti-CMV antibodies cross-reacting in the HHV-6 IgG assay.
已知IgM抗巨细胞病毒（CMV）或IgM抗爱泼斯坦-巴尔病毒（EBV）呈阳性的血清中，高滴度（大于256）IgG抗人疱疹病毒6型（HHV-6）的频率显著高于健康对照者的血清或CMV和EBV IgM均为阴性的一组患病患者的血清（分别为15/25和17/25 对比1/25和2/25，P小于.001）。在17例原发性CMV感染患者的血清中，有14例存在HHV-6同时感染或再激活的血清学证据（IgG抗HHV-6滴度升高或存在IgM抗HHV-6）。在10例两种病毒的IgG滴度同时升高的患者中，有5例IgG抗HHV-6的升高先于IgG抗CMV的升高。从5例原发性CMV感染且IgG抗HHV-6滴度升高的患者血清中完全去除IgG抗CMV反应性，对这些血清的IgG抗HHV-6滴度没有影响，这表明HHV-6 IgG滴度的升高不是抗CMV抗体在HHV-6 IgG检测中交叉反应的结果。
