Willems L, Heremans H, Chen G, Portetelle D, Billiau A, Burny A, Kettmann R
Faculty of Agronomy, Gembloux, Belgium.
EMBO J. 1990 May;9(5):1577-81. doi: 10.1002/j.1460-2075.1990.tb08277.x.
Human T-lymphotropic viruses (HTLV-I and -II) and bovine leukaemia virus (BLV) express transactivator proteins able to increase long terminal repeat (LTR) directed viral expression. These transacting factors are though to be involved in the induction of leukaemia by these viruses. Transfection of BLV transactivator p34tax together with Ha-ras immortalizes and transforms rat embryo fibroblasts, in vitro. The transformed cell induce tumours in nude mice. These data emphasize the causal role exerted by p34tax in in vivo tumorigenesis.
人类嗜T淋巴细胞病毒（HTLV - I和 - II）以及牛白血病病毒（BLV）表达的反式激活蛋白能够增强长末端重复序列（LTR）介导的病毒表达。这些反式作用因子被认为与这些病毒诱发白血病有关。在体外，将BLV反式激活因子p34tax与Ha - ras一起转染可使大鼠胚胎成纤维细胞永生化并发生转化。转化后的细胞可在裸鼠体内诱发肿瘤。这些数据强调了p34tax在体内肿瘤发生中所起的因果作用。
