Rosen C A, Sodroski J G, Willems L, Kettmann R, Campbell K, Zaya R, Burny A, Haseltine W A
EMBO J. 1986 Oct;5(10):2585-9. doi: 10.1002/j.1460-2075.1986.tb04538.x.
The genome of bovine leukemia virus (BLV) contains several overlapping, long open reading frames 3' to the envelope gene. Experiments presented here show that the cDNA encompassing the X region open reading frames encodes a trans-activator function capable of increasing the level of gene expression directed by the BLV long terminal repeat sequences. This study provides further evidence of the structural and functional similarities of the bovine leukemia virus and the human T lymphotropic viruses, HTLV-I and HTLV-II.
牛白血病病毒（BLV）的基因组在包膜基因的3'端包含几个重叠的长开放阅读框。本文所展示的实验表明，包含X区域开放阅读框的cDNA编码一种反式激活功能，能够提高由BLV长末端重复序列指导的基因表达水平。这项研究进一步证明了牛白血病病毒与人类嗜T淋巴细胞病毒HTLV-I和HTLV-II在结构和功能上的相似性。
