Hediger Mary L, England Lucinda J, Molloy Cynthia A, Yu Kai F, Manning-Courtney Patricia, Mills James L
Division-of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7510, USA.
J Autism Dev Disord. 2008 May;38(5):848-56. doi: 10.1007/s10803-007-0453-6.
Bone development, casein-free diet use, supplements, and medications were assessed for 75 boys with autism or autism spectrum disorder, ages 4-8 years. Second metacarpal bone cortical thickness (BCT), measured on hand-wrist radiographs, and % deviations in BCT from reference medians were derived. BCT increased with age, but % deviations evidenced a progressive fall-off (p = .02): +3.1 +/- 4.7%, -6.5 +/- 4.0%, -16.6 +/- 3.4%, -19.4 +/- 3.7%,-24.1 +/- 4.4%, at ages 4-8, respectively, adjusting for height. The 12% of the boys on casein-free diets had an overall % deviation of -18.9 +/- 3.7%, nearly twice that of boys on minimally restricted or unrestricted diets (-10.5 +/- 1.3%, p < .04), although even for boys on minimally restricted or unrestricted diets the % deviation was highly significant (p < .001). Our data suggest that the bone development of autistic boys should be monitored as part of routine care, especially if they are on casein-free diets.
对75名年龄在4至8岁之间患自闭症或自闭症谱系障碍的男孩，评估了其骨骼发育、无酪蛋白饮食的使用情况、补充剂及药物使用情况。通过手腕X光片测量第二掌骨皮质厚度（BCT），并得出BCT相对于参考中位数的百分比偏差。BCT随年龄增长，但百分比偏差呈逐渐下降趋势（p = 0.02）：在4至8岁时，经身高校正后，分别为+3.1±4.7%、-6.5±4.0%、-16.6±3.4%、-19.4±3.7%、-24.1±4.4%。食用无酪蛋白饮食的男孩中，12%的总体百分比偏差为-18.9±3.7%，几乎是食用最低限度限制或无限制饮食男孩的两倍（-10.5±1.3%，p < 0.04），不过即使是食用最低限度限制或无限制饮食的男孩，其百分比偏差也非常显著（p < 0.001）。我们的数据表明，自闭症男孩的骨骼发育应作为常规护理的一部分进行监测，尤其是当他们食用无酪蛋白饮食时。
