Calarge Chadi A, Schlechte Janet A
Menninger Department of Psychiatry and Behavioral Science and Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, 1102 Bates Ave, Suite 790, Houston, TX, 77030, USA.
Department of Internal Medicine, The University of Iowa Carver College of Medicine, Iowa City, 52242, IA, USA.
J Autism Dev Disord. 2017 Jun;47(6):1749-1755. doi: 10.1007/s10803-017-3097-1.
To examine bone mass in children and adolescents with autism spectrum disorders (ASD). Risperidone-treated 5 to 17 year-old males underwent anthropometric and bone measurements, using dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. Multivariable linear regression analysis models examined whether skeletal outcomes differed among participants with (n = 30) versus without ASD (n = 156). After adjusting for potential covariates, having ASD was associated with significantly lower trabecular bone mineral density and bone strength at the radius, and with marginally lower total body less head bone mineral content (p < 0.09). No differences at the lumbar spine were observed. ASD are associated with lower bone mass. Future studies should investigate interventions to optimize skeletal health in ASD.
为了检测自闭症谱系障碍（ASD）儿童和青少年的骨量。对接受利培酮治疗的5至17岁男性进行人体测量和骨测量，采用双能X线吸收法和外周定量计算机断层扫描。多变量线性回归分析模型检验了患有ASD（n = 30）与未患有ASD（n = 156）的参与者之间骨骼指标是否存在差异。在对潜在协变量进行校正后，患有ASD与桡骨小梁骨矿物质密度和骨强度显著降低以及全身（不包括头部）骨矿物质含量略低有关（p < 0.09）。在腰椎未观察到差异。ASD与较低的骨量有关。未来的研究应调查优化ASD患者骨骼健康的干预措施。
