Center for Autism and Related Disorders, Kennedy Krieger Institute, 3901 Greenspring Avenue, Baltimore, MD 21211, USA.
J Autism Dev Disord. 2012 Apr;42(4):575-84. doi: 10.1007/s10803-011-1282-1.
Parents' concerns about their children's development were examined prospectively at 14, 24, and 36 months for 89 younger siblings of a child with autism. Parent reported concern was high at all ages (40-75%) and was higher at 24 and 36 months in children with ASD than non-ASD outcomes (p < .05). Communication concerns were reported most frequently. Parent concern compared to impairment classification based on concurrent standardized tests provided better specificity than sensitivity, and was better for communication than social functioning. Parent communication concern (but not social concern) at 24 months and 36 months predicted ASD versus non-ASD outcome; however, children's impairment on standardized tests yielded greater predictive value at all ages (p < .001). Close monitoring of this at risk group is warranted.
前瞻性地在 14、24 和 36 个月时检查了 89 名自闭症儿童的弟弟妹妹的父母对孩子发育的担忧。在所有年龄段(40-75%),父母的担忧都很高,并且在有 ASD 的儿童中,24 个月和 36 个月时的担忧比非 ASD 结果(p<.05)更高。最常报告的是沟通问题。与基于同期标准化测试的损伤分类相比,父母的担忧提供了更好的特异性而非敏感性,在沟通方面比社交功能更好。24 个月和 36 个月时父母的沟通担忧(但不是社交担忧)可以预测 ASD 与非 ASD 的结果;然而,儿童在标准化测试中的障碍在所有年龄段都具有更大的预测价值(p<.001)。需要对这一高危群体进行密切监测。