Nobakht Hossein, Boghratian Amirhossein, Sohrabi Masoudreza, Panahian Mohammad, Rakhshani Naser, Nikkhah Mehdi, Ajdarkosh Hossein, Hemmasi Gholamreza, Khonsari Mahmoodreza, Gholami Ali, Rabiei Neda, Zamani Farhad
GastroIntestinal and Liver Disease Research Centre (GILDRC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran ; Department of Internal Medicine , Semnan University of Medical Sciences , Semnan ,Iran.
GastroIntestinal and Liver Disease Research Centre (GILDRC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran ; Department of Gastroenterology, RasolAkram Hospital, Iran University of Medical Sciences.Tehran,Iran.
Middle East J Dig Dis. 2016 Jul;8(3):206-211. doi: 10.15171/mejdd.2016.33.
BACKGROUND Reflux disease is a common gastrointestinal problem. The association between reflux disease and gastritis pattern is controversial.
To determine the association between reflux disease and gastritis pattern in patients with infection. METHODS 470 patients with dyspepsia and reflux disease were enrolled in this study. The inclusion criteria were willing to participate in the study, age over 40 years, and having the criteria of ROME III for at least 3 months. Patients with history of eradication therapy during the 3 months before the study, a history of gastric surgery, and gastric cancer were excluded. All of the participants underwent upper endoscopy and two biopsy samples were taken from antrum, body, and fundal areas. RESULTS infection rate was 367 (78.1%) with mean age of 59.8 ± 11.4 years. Of them 131 patients (35.7%) were male. Reflux disease was detected in 273 (74.4%) patients. 216 (58.9%) and 102 (27.8%) patients had non-erosive reflux disease (NERD) and gastroesophageal reflux disease (GERD), respectively. Corpus predominant and antral predominant gastritis were seen in 72 (19.6%) and 129 (35.2%) patients, respectively. Antral gastritis was significantly associated with GERD (<0.01). In regression analysis, antral predominant gastritis had a significant association with GERD (OR=1.92; 95%CI: 1.22- 3.12). The same result was observed in mild to moderate antral and greater curvature gastritis (OR= 1.26; 95%CI: 0.25-6.40 and OR= 3.0; 95%CI: 0.63-14.17, respectively). CONCLUSION According to these finding ,we could suggest that the pattern of gastritis could be associated with reflux disease and GERD.
背景 反流性疾病是一种常见的胃肠道问题。反流性疾病与胃炎类型之间的关联存在争议。
确定感染患者中反流性疾病与胃炎类型之间的关联。方法 本研究纳入了470例消化不良和反流性疾病患者。纳入标准为愿意参与研究、年龄超过40岁且符合罗马III标准至少3个月。排除研究前3个月内有根除治疗史、胃手术史和胃癌史的患者。所有参与者均接受了上消化道内镜检查，并从胃窦、胃体和胃底区域采集了两份活检样本。结果 感染率为367例（78.1%），平均年龄为59.8±11.4岁。其中131例患者（35.7%）为男性。273例（74.4%）患者检测出反流性疾病。216例（58.9%）和102例（27.8%）患者分别患有非糜烂性反流病（NERD）和胃食管反流病（GERD）。分别有72例（19.6%）和129例（35.2%）患者出现胃体为主型和胃窦为主型胃炎。胃窦胃炎与GERD显著相关（<0.01）。在回归分析中，胃窦为主型胃炎与GERD显著相关（OR=1.92；95%CI：1.22-3.12）。在轻度至中度胃窦和大弯胃炎中也观察到相同结果（OR分别为1.26；95%CI：0.25-6.40和OR=3.0；95%CI：0.63-14.17）。结论 根据这些发现，我们可以认为胃炎类型可能与反流性疾病和GERD有关。
