Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Neurocrit Care. 2011 Dec;15(3):554-8. doi: 10.1007/s12028-011-9555-2.
Terson's syndrome is intraocular hemorrhage (IOH) subsequent to subarachnoid hemorrhage (SAH). Its presence is associated with higher mortality in SAH. We report a case of Terson's syndrome and review the literature.
A 71-year-old Caucasian gentleman collapsed and became comatose. Past medical history was notable for chronic anticoagulation for previous transient ischemia attacks. CT head scans showed severe SAH of Fisher grade 4 and a lesion suspicious for aneurysm. Formal angiography confirmed a supraclinoid right internal carotid artery aneurysm which was coiled. ICU admission was complicated by a stormy course. The patient eventually regained consciousness and was transferred to a regular ward. On hospital day 20, impaired vision was noted. Review of CT head scans revealed previously missed retinal hemorrhages and funduscopy confirmed vitreous hemorrhage. However, the patient remained in a poor neurologic state and expired several days later.
Terson's syndrome occurs in up to 40% of acute aneurysmal bleeds. The sudden spike in intracranial pressure (ICP) with aneurysmal rupture is thought to underlie the cause of IOH as well as the high incidence of coma, higher Hunt and Hess grades, and mortality in these patients. Gold-standard diagnosis is funduscopy, and retinal hemorrhages may occasionally be seen on CT.
Terson's syndrome occurs frequently following SAH, although it is under-reported. Suspected visual loss following SAH should prompt a search for Terson's syndrome by funduscopy, as its presence is an adverse prognostic factor.
Terson 综合征是蛛网膜下腔出血(SAH)后继发的眼内出血(IOH)。其存在与 SAH 死亡率升高有关。我们报告了一例 Terson 综合征病例,并复习了相关文献。
一名 71 岁的白人男性晕倒并陷入昏迷。既往病史为因短暂性缺血发作而长期接受抗凝治疗。头部 CT 扫描显示 Fisher 分级 4 级严重的 SAH 和疑似动脉瘤的病变。正式的血管造影证实了右侧颈内动脉颅底段的一个动脉瘤,并对其进行了线圈栓塞。入住 ICU 期间病情恶化。患者最终恢复了意识并转入普通病房。在住院的第 20 天,出现视力受损。复查头部 CT 扫描显示先前漏诊的视网膜出血,眼底检查证实玻璃体出血。然而,患者仍处于严重的神经功能状态,并在数天后死亡。
Terson 综合征在急性动脉瘤性出血中发生率高达 40%。动脉瘤破裂导致颅内压(ICP)突然升高,被认为是 IOH 以及这些患者中昏迷、更高的 Hunt 和 Hess 分级以及死亡率高的原因。金标准诊断是眼底检查,视网膜出血偶尔也可见于 CT 上。
Terson 综合征在 SAH 后经常发生,尽管报道较少。SAH 后出现疑似视力丧失时应通过眼底检查寻找 Terson 综合征,因为其存在是一个不利的预后因素。