分子影像探针设计技术。
Techniques for molecular imaging probe design.
机构信息
Robert M. Berne Cardiovascular Research Center and Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
出版信息
Mol Imaging. 2011 Dec;10(6):407-19.
Abstract
Molecular imaging allows clinicians to visualize disease-specific molecules, thereby providing relevant information in the diagnosis and treatment of patients. With advances in genomics and proteomics and underlying mechanisms of disease pathology, the number of targets identified has significantly outpaced the number of developed molecular imaging probes. There has been a concerted effort to bridge this gap with multidisciplinary efforts in chemistry, proteomics, physics, material science, and biology--all essential to progress in molecular imaging probe development. In this review, we discuss target selection, screening techniques, and probe optimization with the aim of developing clinically relevant molecularly targeted imaging agents.
摘要
分子成像使临床医生能够可视化疾病特异性分子，从而为患者的诊断和治疗提供相关信息。随着基因组学和蛋白质组学的进步以及疾病病理的潜在机制的深入了解，已鉴定的靶点数量大大超过了已开发的分子成像探针的数量。人们已经通过化学、蛋白质组学、物理学、材料科学和生物学等多学科的努力来努力缩小这一差距，这些努力对于分子成像探针开发的进展至关重要。在这篇综述中，我们讨论了靶标选择、筛选技术和探针优化，旨在开发临床相关的分子靶向成像剂。
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