Doctorado en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada #950, Col. Independencia, 44348 Guadalajara, Jalisco, Mexico.
Rheumatol Int. 2012 Aug;32(8):2307-11. doi: 10.1007/s00296-011-1951-6. Epub 2011 May 24.
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease of unknown etiology. Many cytokines have been found to be associated with RA pathogenesis and among them is macrophage migration inhibitory factor (MIF). The aim of this study was to determine whether MIF serum levels are associated with RA course, clinical activity, and clinical biomarkers of the disease. MIF levels were determined in serum samples of 54 RA patients and 78 healthy subjects (HS) by enzyme-linked immunosorbent assay (ELISA). Disease activity was evaluated using the DAS28 score. Patients were subgrouped according to disease activity and years of evolution of disease. Statistical analysis was carried out by SPSS 10.0 and GraphPad Prism 5 software. RA patients presented increased levels of MIF as compared to HS. MIF levels were raised on early stages of RA and tend to decrease according to years of evolution. Moreover, MIF levels positively correlated with rheumatoid factor in RA patients and with C reactive protein in all individuals studied. Our findings suggest that MIF plays a role in early stages of RA.
类风湿关节炎（RA）是一种病因不明的炎症性自身免疫性疾病。许多细胞因子已被发现与 RA 的发病机制有关，其中包括巨噬细胞移动抑制因子（MIF）。本研究旨在确定 MIF 血清水平是否与 RA 病程、临床活动和疾病的临床生物标志物有关。采用酶联免疫吸附试验（ELISA）法检测 54 例 RA 患者和 78 例健康对照者（HS）血清样本中的 MIF 水平。采用 DAS28 评分评估疾病活动度。根据疾病活动度和疾病演变年限将患者分组。采用 SPSS 10.0 和 GraphPad Prism 5 软件进行统计学分析。与 HS 相比，RA 患者的 MIF 水平升高。MIF 水平在 RA 的早期阶段升高，并随着疾病的演变而趋于降低。此外，MIF 水平与 RA 患者的类风湿因子呈正相关，与所有研究个体的 C 反应蛋白呈正相关。我们的研究结果表明，MIF 在 RA 的早期阶段发挥作用。
