Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Neuron. 2011 May 26;70(4):589-96. doi: 10.1016/j.neuron.2011.05.010.
Recently, investigation of new neurons in memory formation has focused on a specific function-pattern separation. However, it has been difficult to reconcile the form of separation tested in behavioral tasks with how it is conceptualized according to computational and electrophysiology perspectives. Here, we propose a memory resolution hypothesis that considers the unique information contributions of broadly tuned young neurons and highly specific mature neurons and describe how the fidelity of memories can relate to spatial and contextual discrimination. See the related Perspective from Sahay, Wilson, and Hen, "Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory Bulb," in this issue of Neuron.
最近，在记忆形成中新神经元的研究集中在一个特定的功能——模式分离上。然而，根据计算和电生理学的观点，很难将行为任务中测试的分离形式与概念化的分离形式统一起来。在这里，我们提出了一个记忆分辨率假说，该假说考虑了广泛调谐的年轻神经元和高度特异的成熟神经元的独特信息贡献，并描述了记忆的保真度如何与空间和上下文区分相关。参见相关的观点文章，Sahay、Wilson 和 Hen 的“模式分离：海马和嗅球中新神经元的共同功能”，发表在本期《神经元》杂志上。
