Wciórka Jacek, Schaeffer Ewa, Switaj Piotr, Waszkiewicz Justyna, Krasuska Katarzyna, Wegrzyn Jacek, Woźniak Piotr
I Klinika Psychiatryczna IPiN w Warszawie.
Psychiatr Pol. 2011 Jan-Feb;45(1):61-78.
The Bech-Rafaelsen Mania Rating Scale (BRMAS) and Young Mania Rating Scale (YMRS) are both popular rating scales for mania. Until now BRMAS has not had a Polish language version BRMAS, although it may be particularly useful because of its twin depression (melancholia) rating scale (BRMES). No attempt of evaluation of the scales were made in Poland until now. Attempts to compare their worth are rare in the literature. The aim of this study was to evaluate and compare the two scales.
Thirty-five patients hospitalised for mania in the course of affective, schizophrenic and organic disorders were assessed by means of two mania rating scales (BRMAS, YRMS), as well as with clinical global impression (CGI) scale, and its parallel versions for mania (CGI-M) and treatment adverse events (CGI-SE). Two rating scales for psychotic syndromes (PANSS, KOSS-S) was also used. Patients were assessed three times. First three diagnosticians evaluated simultaneously and independently the patients' mental state, and then--after one and two weeks--one of them. As reliability measures, inter-rater, test-retest, and internal consistency indices were analysed. As validity measures, a clinical meaning of descriptive characteristics of the scales (external validity), and a comparison with alternative tools for mania rating (criterion, diagnostic validity) were performed. Specificity and sensitivity of BRMAS and YMRS in relation to clinical criterion of severe mania (CGI > or = 5) was analysed by means of ROC curve. As feasibility measure observations made during assessments were used.
BRMAS and YMRS revealed satisfactory convergence between assessments of the three diagnosticians (Spearman's rho > 0.72, no significant difference in non-parametric Friedman test), repeatability after a week (rho > 0.52) and internal consistency (Cronbach's alpha for BRMAS > 0.86, for YMRS > 0.73). Profile and dynamics of symptoms in the three successive assessments (each week) depicted changes consistent with expectations, which proved external validity of the scales. Mutual, high correlations between the BRMAS and YMRS (rho > 0.90), between them and CGI-M scale (rho >77), and between them and some meaningful items of psychosis rating scales (PANSS, KOSS-S) may be a mark of their diagnostic validity. ROC for both scales revealed similar, extensive areas under curve (AUC > 0.947; p < 0.000). BRMAS score above 24 points predicted severe mania with 92% sensitivity and 91% specificity. By analogy, YRMAS score above 29 points allowed this diagnosis with 83% sensitivity and 91% specificity. Practically no difficulties in application of the scale under study were noted.
Both compared mania scales revealed satisfactory indices of reliability and validity. They are also feasible tools. However limited size of the group under study has not allowed more penetrating analysis, particularly that of validity. This is why the study requires continuation.
贝克-拉法尔森躁狂评定量表(BRMAS)和杨氏躁狂评定量表(YMRS)都是常用的躁狂评定量表。到目前为止,BRMAS尚无波兰语版本,尽管因其双相抑郁(忧郁症)评定量表(BRMES)可能特别有用。到目前为止,波兰尚未对这些量表进行评估。文献中很少有比较它们价值的尝试。本研究的目的是评估和比较这两个量表。
通过两个躁狂评定量表(BRMAS、YRMS)以及临床总体印象(CGI)量表及其躁狂平行版本(CGI-M)和治疗不良事件(CGI-SE),对35例因情感性、精神分裂症性和器质性障碍住院的躁狂患者进行评估。还使用了两个精神病综合征评定量表(PANSS、KOSS-S)。对患者进行了三次评估。首先,三名诊断医生同时独立评估患者的精神状态,然后在一周和两周后由其中一人进行评估。作为可靠性指标,分析了评定者间、重测和内部一致性指数。作为效度指标,对量表描述性特征的临床意义(外部效度)以及与躁狂评定替代工具的比较(标准、诊断效度)进行了评估。通过ROC曲线分析了BRMAS和YMRS相对于重度躁狂临床标准(CGI≥5)的特异性和敏感性。以评估期间的观察结果作为可行性指标。
BRMAS和YMRS显示三名诊断医生的评估之间具有令人满意的一致性(Spearman等级相关系数>0.72,非参数弗里德曼检验无显著差异),一周后的重复性(等级相关系数>0.52)和内部一致性(BRMAS的Cronbach's α>0.86,YMRS的Cronbach's α>0.73)。连续三次评估(每周一次)中症状的概况和动态变化符合预期,证明了量表的外部效度。BRMAS和YMRS之间、它们与CGI-M量表之间(等级相关系数>0.77)以及它们与精神病评定量表的一些有意义项目(PANSS、KOSS-S)之间相互高度相关,可能是其诊断效度的标志。两个量表的ROC曲线显示曲线下面积相似且较大(AUC>0.947;p<0.000)。BRMAS得分高于24分预测重度躁狂的敏感性为92%,特异性为91%。类似地,YRMAS得分高于29分进行该诊断的敏感性为83%,特异性为91%。在应用所研究的量表时几乎没有遇到困难。
两个比较的躁狂量表都显示出令人满意的可靠性和效度指标。它们也是可行的工具。然而,所研究组的规模有限,无法进行更深入的分析,尤其是效度分析。这就是为什么该研究需要继续进行。