Rome, Italy From the Department of Plastic and Reconstructive Surgery, Catholic University of Sacro Cuore, University Hospital Agostino Gemelli; and Department of Oculoplastics, San Carlo di Nancy Hospital.
Plast Reconstr Surg. 2011 Jun;127(6):2176-2185. doi: 10.1097/PRS.0b013e3182139fe7.
The role of platelet-rich plasma in enhancing fat graft take is attracting the scientific community. There is, however, a lack of clinical studies on the matter. The aim of this article is to report the authors' experience in breast fat grafting with and without platelet-rich plasma and to investigate the state of the art on adipose tissue platelet-rich plasma enrichment.
The authors retrospectively reviewed 42 women who underwent breast fat grafting between September of 2007 and September of 2009. Seventeen of these patients (40 percent) were grafted with fat (according to Coleman) enriched with platelet-rich plasma at 10 percent (group A), and 25 patients (60 percent) received only fat grafts according to Coleman (group B). All patients underwent preoperative breast ultrasound and mammography and were regularly followed up with breast ultrasound 3 months later and then at 6-month intervals. The reconstructive and aesthetic outcomes were evaluated using the following parameters: (1) clinical outcomes according to the surgeons and the patient, (2) the rate of liponecrosis at breast ultrasound, and (3) the need of further fat grafting to achieve the planned result.
The clinical outcomes, the rate of liponecrosis at breast ultrasound, and the need for further fat grafting reveal that fat grafting plus platelet-rich plasma at 10 percent is not superior to Coleman fat grafting alone.
In the authors' retrospective analysis, no effect of platelet-rich plasma was seen in enhancing fat graft take when compared with the Coleman fat graft. Further research and prospective clinical studies are needed to understand the role of platelet-rich plasma, if any, in fat grafting.
富含血小板的血浆在提高脂肪移植物成活率方面的作用正引起科学界的关注。然而，关于这方面的临床研究还很少。本文的目的是报告作者在乳房脂肪移植中使用和不使用富含血小板的血浆的经验，并调查脂肪组织富含血小板的血浆富集的最新技术。
作者回顾性分析了 2007 年 9 月至 2009 年 9 月期间接受乳房脂肪移植的 42 名女性。其中 17 名患者（40%）接受了 10%的富含血小板的血浆（Coleman）脂肪移植（A 组），25 名患者（60%）仅接受了 Coleman 脂肪移植（B 组）。所有患者均接受术前乳房超声和乳房 X 线摄影检查，并在 3 个月后和随后每隔 6 个月进行乳房超声定期随访。采用以下参数评估重建和美学效果：（1）根据外科医生和患者评估的临床结果，（2）乳房超声检查的脂肪坏死发生率，（3）实现计划结果所需的进一步脂肪移植。
临床结果、乳房超声检查的脂肪坏死发生率和进一步脂肪移植的需要表明，10%的富含血小板的血浆与单独的 Coleman 脂肪移植相比并不能提高脂肪移植物的成活率。
在作者的回顾性分析中，与 Coleman 脂肪移植相比，富含血小板的血浆对增强脂肪移植物成活率没有影响。需要进一步的研究和前瞻性临床研究来了解富含血小板的血浆在脂肪移植中的作用（如果有的话）。
