Zhu Hua, Bandara Mahesh B, Vijay Ajay K, Masoudi Simin, Wu Duojia, Willcox Mark D P
Brien Holden Vision Institute, Level 5, North Wing, Rupert Myers Building, University of New South Wales, Sydney, NSW 2052, Australia.
Optom Vis Sci. 2011 Aug;88(8):967-72. doi: 10.1097/OPX.0b013e31821bf976.
The introduction of contact lens multipurpose disinfection solution (MPDS) that can be used in conjunction with a "no-rub" regimen has simplified lens care requirements. Once adhered to a surface, microorganisms can become less susceptible to disinfection. The aim of the study was to evaluate the effect of various regimen steps on the efficacy of MPDS when used with silicone hydrogel and conventional lenses.
Commercially available MPDSs containing polyquad or polyhexamethylene biguanide were used in conjunction with two types of silicone hydrogel (lotrafilcon B and galyfilcon A) and one type of conventional soft contact lenses (etafilcon A). Challenge microorganisms included Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 9027, Serratia marcescens ATCC 13880, Fusarium solani ATCC 36031, Candida albicans ATCC 10231, or Acanthamoeba polyphaga Ros. The effect of regimen steps "rub and rinse," "rinse-only," or "no rub and no rinse" on the disinfection efficacy of test MPDSs was examined using the ISO 14729 Regimen Test procedure.
Overall, the greatest efficacy of MPDSs was observed when "rub and rinse" was performed before disinfection with each of the microorganisms tested, regardless of lens type. "No rub and no rinse" steps resulted in a greater load of microorganisms remaining on lenses compared with the other regimens (p < 0.05). When "rinse-only" was performed before disinfection, the MPDS containing polyquad performed generally better (p < 0.05) than MPDSs containing polyhexamethylene biguanide against bacteria. Significantly, less microorganisms were recovered from galyfilcon A than from other lenses (p < 0.05) when MPDSs were used with "rinse-only" step.
This study has demonstrated that "rub and rinse" is the most effective regimen and should be recommended in conjunction with all multipurpose lens care solutions and all contact lens types, particularly with silicone hydrogel lenses.
可与“免揉搓”方案联合使用的隐形眼镜多功能消毒护理液（MPDS）的引入简化了镜片护理要求。微生物一旦附着在表面，可能会变得对消毒更具抗性。本研究的目的是评估不同护理步骤对MPDS与硅水凝胶镜片和传统镜片联合使用时消毒效果的影响。
将含有聚季铵盐或聚六亚甲基双胍的市售MPDS与两种类型的硅水凝胶（lotrafilcon B和galyfilcon A）以及一种传统软性隐形眼镜（依他氟康A）联合使用。挑战微生物包括金黄色葡萄球菌ATCC 6538、铜绿假单胞菌ATCC 9027、粘质沙雷氏菌ATCC 13880、茄病镰刀菌ATCC 36031、白色念珠菌ATCC 10231或多食棘阿米巴Ros。使用ISO 14729护理方案测试程序，检查“揉搓冲洗”、“仅冲洗”或“免揉搓免冲洗”护理步骤对测试MPDS消毒效果的影响。
总体而言，无论镜片类型如何，在用每种测试微生物进行消毒之前进行“揉搓冲洗”时，观察到MPDS的消毒效果最佳。与其他护理方案相比，“免揉搓免冲洗”步骤导致镜片上残留的微生物数量更多（p < 0.05）。在消毒前进行“仅冲洗”时，含聚季铵盐的MPDS对细菌的消毒效果通常比含聚六亚甲基双胍的MPDS更好（p < 0.05）。值得注意的是，当MPDS与“仅冲洗”步骤联合使用时，从galyfilcon A镜片上回收的微生物明显少于其他镜片（p < 0.05）。
本研究表明，“揉搓冲洗”是最有效的护理方案，应推荐与所有多功能镜片护理液和所有类型的隐形眼镜联合使用，尤其是硅水凝胶镜片。
