Stemline Therapeutics, Inc., 1675 York Avenue, Suite 34-L, New York, NY 10128, USA.
FEBS Lett. 2011 Sep 16;585(18):2803-9. doi: 10.1016/j.febslet.2011.05.022. Epub 2011 May 27.
The ubiquitination pathway is a highly dynamic and coordinated process that regulates degradation as well as numerous processes of proteins within a cell. The p53 tumor suppressor and several factors in the pathway are regulated by ubiquitin as well as ubiquitin-like proteins. These modifications are critical for the function of p53 and control both the degradation of the protein as well as localization and activity. Importantly, more recent studies have identified deubiquitination enzymes that can specifically remove ubiquitin moieties from p53 or other factors in the pathway, and the reversible nature of this process adds yet another layer of regulatory control of p53. This review highlights the recent advances in our knowledge of ubiquitin and the p53 pathway.
泛素化途径是一个高度动态和协调的过程，它调节细胞内蛋白质的降解以及许多过程。p53 肿瘤抑制因子和途径中的几种因子都受到泛素和泛素样蛋白的调节。这些修饰对于 p53 的功能至关重要，控制着蛋白质的降解以及蛋白质的定位和活性。重要的是，最近的研究已经确定了去泛素化酶，它们可以特异性地从 p53 或途径中的其他因子中去除泛素部分，而这个过程的可逆性为 p53 的调控增加了另一层。本综述强调了我们对泛素和 p53 途径的最新认识。
