Dobb G J, Towler S C
Intensive Care Unit, Royal Perth Hospital, Western Australia.
Intensive Care Med. 1990;16(4):252-5. doi: 10.1007/BF01705161.
This randomised double-blind study examined the frequency of diarrhoea in intensive care unit patients given a fibre-containing feed, Enrich, and a fibre-free feed, Ensure. A daily 'diarrhoea score' was calculated from the frequency, volume and consistency of the stools. A score greater than 12 indicated diarrhoea, and greater than 50 severe diarrhoea. Ninety one patients met the criteria for participation: Enrich 45, Ensure 46. The groups were similar in age, sex ratio, feed volume, antibiotic usage, upper gastro-intestinal bleeding prophylaxis and plasma albumin concentrations. Diarrhoea occurred in 16 patients given Enrich and 13 given Ensure, severe diarrhoea affecting 5 and 9 respectively (NS). Forty seven of 343 (14%) Enrich feeding days and 51 of 342 (15%) Ensure feeding days were complicated by diarrhoea--severe diarrhoea: 8 and 12 feeding days (NS). We conclude soy polysaccharide (21 g/L) did not reduce diarrhoea in intensive care unit patients given enteral feeds.
这项随机双盲研究调查了重症监护病房中接受含纤维配方食品安素（Enrich）和不含纤维配方食品能全素（Ensure）的患者腹泻的发生率。根据粪便的频率、量和稠度计算每日的“腹泻评分”。评分大于12表示腹泻，大于50表示严重腹泻。91名患者符合参与标准：安素组45人，能全素组46人。两组在年龄、性别比例、喂食量、抗生素使用、上消化道出血预防措施及血浆白蛋白浓度方面相似。接受安素的患者中有16人出现腹泻，接受能全素的患者中有13人出现腹泻，严重腹泻分别影响5人和9人（无统计学差异）。安素喂食的343天中有47天（14%）出现腹泻并发症，能全素喂食的342天中有51天（15%）出现腹泻并发症——严重腹泻分别为8天和12天（无统计学差异）。我们得出结论，对于接受肠内喂养的重症监护病房患者，大豆多糖（21克/升）并不能减少腹泻的发生。
