Bird A S, Blizard R A, Mann A H
Academic Department of Psychiatry, Royal Free Hospital, London, UK.
J Hypertens. 1990 Feb;8(2):147-52. doi: 10.1097/00004872-199002000-00008.
No adverse effect upon cognitive function has been detected during the first 9 months of treatment by a thiazide diuretic (Moduretic; Merck Sharp & Dohme, Hoddesdon, UK) or a beta-blocking agent (atenolol) of moderately elevated blood pressure in a cohort of 2630 men and women aged between 65 and 74 years. Furthermore, no association was discovered between levels of systolic or diastolic blood pressure at outset and responses to standard tests of cognitive function. This study was carried out in general practices as part of the current Medical Research Council Treatment Trial of Mild Hypertension in the Elderly.
在一项针对2630名年龄在65至74岁之间的男性和女性的研究中，使用噻嗪类利尿剂（复方阿米洛利；默克夏普&多贺美公司，英国霍德斯顿）或β受体阻滞剂（阿替洛尔）治疗血压中度升高的患者，在治疗的前9个月未检测到对认知功能有不良影响。此外，在研究开始时的收缩压或舒张压水平与认知功能标准测试的反应之间未发现关联。这项研究是在普通诊所进行的，是当前医学研究委员会老年人轻度高血压治疗试验的一部分。
