University of Pittsburgh, Department of Psychiatry, 3811 O'Hara Street, Pittsburgh, PA 15213, USA.
Sleep. 2011 Jun 1;34(6):711-6. doi: 10.5665/SLEEP.1032.
Short and less efficient sleep may be risk factors for atherosclerosis. Few studies have investigated the associations between sleep characteristics and early cardiovascular disease (CVD) risk.
Evaluate the associations between coronary artery calcification (CAC) and Framingham risk score profile with sleep characteristics in middle-aged men and women with no history of diagnosed myocardial infarction, interventional cardiology procedures, stroke, diabetes, or sleep disorders.
224 participants enrolled in an epidemiological study of disparities in CVD risk were recruited for a 9-night assessment of sleep, with 2 nights of polysomnography (PSG) and 9 nights of actigraphy and sleep diaries. Of the 224 participants, 110 had high/moderate Framingham risk scores and 114 had low scores; 195 had computed tomography measures of CAC.
Individuals who had any CAC or higher Framingham risk scores had elevated apnea/hypopnea index (AHI) values, independent of age, race, and gender. The AHI association with CAC was nonsignificant in analyses adjusting for body mass index (BMI). Those with higher Framingham risk score profiles had shorter PSG sleep duration and less percent stage 3-4 and delta power sleep. High blood pressure and left ventricular hypertrophy were related to AHI and sleep duration, independent of BMI. Neither sleep duration nor efficiency was associated with CAC.
CAC was not associated with AHI, independent of BMI in a community-based sample of middle-aged men and women. Framingham risk score profiles were related to poor sleep. Sleep duration may not be related to early plaque burden in relatively healthy individuals.
短暂且效率低下的睡眠可能是动脉粥样硬化的危险因素。很少有研究调查睡眠特征与早期心血管疾病（CVD）风险之间的关系。
评估无明确心肌梗死、介入心脏病学程序、中风、糖尿病或睡眠障碍史的中年男女的冠状动脉钙化（CAC）和弗雷明汉风险评分与睡眠特征之间的关联。
招募了 224 名参与 CVD 风险差异的流行病学研究的参与者，进行了为期 9 晚的睡眠评估，包括 2 晚的多导睡眠图（PSG）和 9 晚的活动记录仪和睡眠日记。在 224 名参与者中，110 人具有高/中度弗雷明汉风险评分，114 人具有低评分；195 人具有 CAC 的计算机断层扫描测量值。
无论年龄、种族和性别如何，任何 CAC 或更高弗雷明汉风险评分的个体的呼吸暂停/低通气指数（AHI）值均升高。在调整体重指数（BMI）后，AHI 与 CAC 的关联无统计学意义。那些具有更高的弗雷明汉风险评分的人 PSG 睡眠时间较短，第三阶段到第四阶段和 delta 功率睡眠的比例较低。高血压和左心室肥厚与 AHI 和睡眠持续时间有关，与 BMI 无关。无论是睡眠持续时间还是效率都与 CAC 无关。
在基于社区的中年男女样本中，CAC 与 BMI 无关，与 AHI 无关。弗雷明汉风险评分与睡眠质量差有关。在相对健康的个体中，睡眠持续时间可能与早期斑块负担无关。
