氧化组织：脂滴包被蛋白 5 将储存与燃烧联系起来。
Oxidative tissue: perilipin 5 links storage with the furnace.
机构信息
The Geriatric Research, Education and Clinical Center, Baltimore Veterans Affairs Health Care Center, and Division of Endocrinology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA.
出版信息
Trends Endocrinol Metab. 2011 Jun;22(6):197-203. doi: 10.1016/j.tem.2011.03.008. Epub 2011 May 31.
Abstract
Cellular energy homeostasis is a crucial function of oxidative tissues and is altered in obesity, a continuously rising health problem. Lipid droplets (LD) are thought to play a central role in lipid homeostasis by mediating the transient storage of fatty acids in the form of triglyceride, while preventing high levels of toxic lipid intermediates or oxidized lipids that mediate cellular lipotoxicity. Members of the perilipin protein family coating LD surfaces have been found to serve important regulatory and structural functions crucial to the regulation of lipid stores. This review examines the results of studies on one of the newest members of the perilipin family, perilipin 5, which has emerged as a putative key player in LD function in oxidative tissues.
摘要
细胞能量稳态是氧化组织的一项重要功能，在肥胖这种持续上升的健康问题中发生改变。脂滴（LD）被认为在脂质稳态中发挥核心作用，通过将脂肪酸以甘油三酯的形式进行短暂储存，同时防止高水平的有毒脂质中间产物或氧化脂质介导细胞脂肪毒性。发现覆盖 LD 表面的 perilipin 蛋白家族成员具有重要的调节和结构功能，对于脂质储存的调节至关重要。本综述考察了 perilipin 家族最新成员之一 perilipin 5 的研究结果，perilipin 5 已成为氧化组织中 LD 功能的一个假定关键因子。
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