Department of Cell Biology, Duke University Medical Center, Durham, USA.
Cell Div. 2011 Jun 6;6(1):12. doi: 10.1186/1747-1028-6-12.
For proper tissue morphogenesis, cell divisions and cell fate decisions must be tightly and coordinately regulated. One elegant way to accomplish this is to couple them with asymmetric cell divisions. Progenitor cells in the developing epidermis undergo both symmetric and asymmetric cell divisions to balance surface area growth with the generation of differentiated cell layers. Here we review the molecular machinery implicated in controlling asymmetric cell division. In addition, we discuss the ability of epidermal progenitors to choose between symmetric and asymmetric divisions and the key regulatory points that control this decision.
为了实现组织形态发生，细胞分裂和细胞命运决定必须紧密协调地进行调控。一种实现这一目标的巧妙方法是将它们与不对称细胞分裂相结合。发育中的表皮中的祖细胞经历对称和不对称细胞分裂，以平衡表面积生长和分化细胞层的产生。本文综述了参与控制不对称细胞分裂的分子机制。此外，我们还讨论了表皮祖细胞在对称和不对称分裂之间进行选择的能力，以及控制这一决定的关键调节点。
