Central Animal Laboratory, University of Turku, Kiinamyllynkatu 10, C6, FIN-20520 Turku, Finland.
Vet J. 2012 Apr;192(1):123-5. doi: 10.1016/j.tvjl.2011.04.024. Epub 2011 Jun 8.
(51)Chromium-labeled ethylenediamine tetra-acetic acid ((51)Cr-EDTA) is the gold standard probe for assessing intestinal permeability (IP) in dogs, but exposure to radioactivity is a disadvantage. Iohexol is a safe contrast medium commonly used for medical imaging purposes and has been successfully applied more recently for the assessment of IP in animal models and humans. This study aimed at comparing (51)Cr-EDTA and iohexol as IP blood markers in dogs. A test solution containing (51)Cr-EDTA and iohexol was administered intragastrically to seven healthy laboratory Beagle dogs, and percentage recoveries in serum were calculated. The strong linear association (correlation, r=0.76 and linear regression, y=0.03+5.04x) between (51)Cr-EDTA and iohexol supports the potential usefulness of iohexol as an IP blood marker in dogs.
（51）铬标记的乙二胺四乙酸（（51）Cr-EDTA）是评估犬肠道通透性（IP）的金标准探针，但接触放射性是其缺点。碘海醇是一种安全的造影剂，常用于医学成像目的，最近也成功应用于动物模型和人类的 IP 评估。本研究旨在比较（51）Cr-EDTA 和碘海醇作为犬肠道通透性的血液标志物。将含有（51）Cr-EDTA 和碘海醇的测试溶液经胃内给予 7 只健康的实验室比格犬，并计算血清中的回收率。（51）Cr-EDTA 和碘海醇之间存在很强的线性关联（相关性，r=0.76 和线性回归，y=0.03+5.04x），支持碘海醇作为犬肠道通透性的血液标志物具有潜在的用途。
