CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, The People's Republic of China.
J Virol. 2011 Aug;85(16):8431-5. doi: 10.1128/JVI.00638-11. Epub 2011 Jun 8.
There are 9 serotypes of neuraminidase (NA) from influenza A virus (N1 to N9), which are classified into two groups based on primary sequences (groups 1 and 2). The structural hallmark of the two groups is the presence or absence of an extra 150-cavity (formed by the 150-loop) in the active site. Thus far, structures of NAs from 6 out of the 9 serotypes have been solved. Here, we solved the N5 structure, the last unknown structure group 1 serotype with a unique Asn147 residue in its 150-loop, demonstrating that it has an extended 150-cavity that closes upon inhibitor binding.
有 9 种神经氨酸酶（NA）血清型来自甲型流感病毒（N1 至 N9），根据一级序列将其分为两组（1 组和 2 组）。两组的结构标志是活性部位是否存在额外的 150 腔（由 150 环形成）。到目前为止，已经解决了 9 种血清型中的 6 种 NA 的结构。在这里，我们解决了 N5 结构，这是最后一个未知的组 1 血清型结构，其 150 环中的一个独特的天冬酰胺 147 残基，表明它具有扩展的 150 腔，在抑制剂结合时会关闭。
