一类独特的胚胎蛋白酪氨酸激酶受体家族。
A distinctive family of embryonic protein-tyrosine kinase receptors.
作者信息
Pasquale E B
机构信息
Department of Biology, University of California, San Diego, La Jolla 92093.
出版信息
Proc Natl Acad Sci U S A. 1990 Aug;87(15):5812-6. doi: 10.1073/pnas.87.15.5812.
Abstract
Two closely related protein-tyrosine kinases with the characteristics of growth factor receptors were identified by screening a chicken embryo cDNA expression library with anti-phosphotyrosine antibodies and were designated Cek2 and Cek3 (chicken embryo kinases 2 and 3). Cek2 and Cek3 are structurally related to Cek1, a chicken basic fibroblast growth factor receptor, and presumably represent receptors for basic fibroblast growth factor-related molecules. The identification of Cek2 and Cek3 establishes the existence of a family of protein-tyrosine kinases that includes Cek1 and that is likely to be implicated in the control of developmental processes. Among protein-tyrosine kinases, this family of receptors, which may include other as yet unknown members, is most closely related to the protooncogene product Ret and the platelet-derived growth factor receptor family.
摘要
通过用抗磷酸酪氨酸抗体筛选鸡胚cDNA表达文库，鉴定出了两种具有生长因子受体特征的密切相关的蛋白酪氨酸激酶，并将其命名为Cek2和Cek3（鸡胚激酶2和3）。Cek2和Cek3在结构上与鸡碱性成纤维细胞生长因子受体Cek1相关，推测代表碱性成纤维细胞生长因子相关分子的受体。Cek2和Cek3的鉴定证实了一个包括Cek1的蛋白酪氨酸激酶家族的存在，该家族可能与发育过程的控制有关。在蛋白酪氨酸激酶中，这个可能包括其他未知成员的受体家族与原癌基因产物Ret和血小板衍生生长因子受体家族关系最为密切。
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